Grant-in-Aid for Scientific Research on Innovative AreasPrecise Formation of a Catalyst Having a Specified Field for Use in Extremely Difficult Substrate Conversion Reactions

Naoya Kumagai » Japanese

Affiliation Institute of Microbial Chemistry
Position Chief Researcher
Contact Email
HP http://www.bikaken.or.jp/research/group/shibasaki/shibasaki-lab/index_e.html
Speciality Organic Synthesis・Asymmetric Catalysis
Keyword asymmetric catalysis • organic synthesis
Institute The pharmaceutical society of japan • The Chemical Society of Japan • American Chemical Society • The Society of Synthetic Organic Chemistry, Japan • The Society of Fluorine Chemistry, Japan

Abstract

Exploratory Research of Catalytic Reactions Based on B3NO2 Exotic Heterocycle

Achievement

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Original papers

  • Z-Enolate Geometry in the Thioamide Aldol Reaction Illuminated by the 7-Azaindoline Auxiliary
    Pluta, R.; Li, Z.; *Kumagai, N.; *Shibasaki, M.
    Org. Lett., 2020, 22, 791-794
  • TriQuinoline
    Adachi, S.; *Shibasaki, M.; *Kumagai, N.
    Nat. Commun., 2019, 10, Article number: 3820
  • Direct Catalytic Asymmetric Addition of Acetonitrile to Aldimines
    Saito, A.; *Kumagai, N.; *Shibasaki, M.
    Org. Lett., 2019, 21, 8187-8190
  • A Thirst for Enantioselectivity in Catalytic Addition of Alkylnitriles
    *Kumagai, N.; *Shibasaki, M.
    Chem. Lett., 2019, 48, 1322-1327
  • "Solvent-Dependent Enantiodivergence in anti-Selective Catalytic Asymmetric Nitroaldol Reactions"
    Karasawa, T.; Saito, A.; *Kumagai, N.; *Shibasaki, M.
    Org. Lett., 2019, 21, 3581-3583
  • "Catalytic Asymmetric Synthesis of syn Aldols with Methyl Ketone Functionality and anti Aldols with a Thioamide Group"
    Ota, Y.; Li, Z.; *Kumagai, N.; *Shibasaki, M.
    Synlett, 2019, 30(5), 620-624
  • "Direct Catalytic Asymmetric Mannich-Type Reaction of an α-CF3 Amide to Isatin Imines"
    Yu, J.-S.; Noda, H.; *Kumagai, N.; *Shibasaki, M.
    Synlett , 2019, 30(4), 488-492
  • "All Non‐Carbon B3NO2 Exotic Heterocycles: Synthesis, Dynamics, and Catalysis"
    Opie, C. R.; Noda, H.; *Shibasaki, M.; *Kumagai, N.
    Chem. Eur. J. , 2019, 25(18), 4648-4653
  • "A C4N4 Diaminopyrimidine Fluorophore"
    Noda, H.; Asada, Y.; Maruyama, T.; Takizawa, N.; Noda, N. N.; *Shibasaki, M.; *Kumagai, N.
    Chem. Eur. J., 2019, 25(17), 4299-4304
  • "Direct Catalytic Asymmetric Aldol Reaction of α‐Alkoxyamides to α‐Fluorinated Ketones"
    Pluta, R.; *Kumagai, N.; *Shibasaki, M.
    Angew. Chem. Int. Ed., 2019, 58(8), 2459-2463
  • "Neighboring Protonation Unveils Lewis Acidity in the B3NO2 Heterocycle"
    Noda, H.; Asada, Y.; *Shibasaki, M.; *Kumagai, N.
    J. Am. Chem. Soc. , 2019, 141(4), 1546–1554
  • "A fluorogenic C4N4 probe for azide-based labelling"
    Noda, H.; Asada, Y.; Shibasaki, M.; *Kumagai, N.
    Org. Biomol. Chem., 2019, 17, 1813-1816
  • "7-Azaindoline Auxiliary: A Versatile Attachment Facilitating Enantioselective C-C Bond-Forming Catalysis"
    *Kumagai, N.; *Shibasaki, M.
    Synthesis, 2019, 51(1), 185-193
  • "Achiral Trisubstituted Thioureas as Secondary Ligands to Cu(I) Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines"
    Balaji, P. V.; Brewitz, L.; *Kumagai, N.; *Shibasaki, M.
    Angew. Chem., Int. Ed., , 2019, 58(9), 2644-2648
  • "anti-Selective Catalytic Asymmetric Nitroaldol Reaction of α-Keto Esters; Intriguing Solvent Effect, Flow Reaction, and Synthesis of APIs"
    Karasawa, T.; Oriez, R.; *Kumagai, N.; *Shibasaki, M.
    J. Am. Chem. Soc., 2018, 140(38), 12290–12295
  • "Direct Catalytic Asymmetric 1,6-Conjugate Addition of Amides to p-Quinone Methides"
    Sun, Z.; Sun, B.; *Kumagai, N.; *Shibasaki, M.
    Org. Lett. , 2018, 20(10), 3070–3073
  • "Direct Catalytic Asymmetric Aldol Reaction of α-Vinyl Acetamide"
    Takeuchi, T.; *Kumagai, N.; *Shibasaki, M.
    J. Org. Chem. , 2018, 83(10), 5851–5858
  • "Direct Enolization Chemistry of 7-Azaindoline Amides: A Case Study of Bis(Ttetrahydrophosphole)-Type Ligands"
    Li, Z.; Noda, H.; *Kumagai, N.; *Shibasaki, M.
    Tetrahedron Lett., , 2018, 74(26), 3301-3305
  • "Catalytic Asymmetric Synthesis of α-Trifluoromethylated Carbinols: A Case Study of Tertiary Propargylic Alcohols"
    Noda, H.; *Kumagai, N.; *Shibasaki, M.
    Asian J. Org. Chem, 2018, , ー
  • "Conquering amide planarity: structural distortion and its hidden reactivity"
    Adachi, S.; *Kumagai, N.; *Shibasaki, M
    Tetrahedron Lett., 2018, , ー
  • "Catalytic Oligopeptide Synthesis"
    Liu, Z.; Noda, H.; *Shibasaki, M.; *Kumagai, N.
    Org. Lett., 2018, 20, 612–615
  • "Heterogeneous Heterobimetallic Catalysis Enabling Expeditious Access to CF3-Containing vic-Amino Alcohols"
    Karasawa, T.; *Kumagai, N.; *Shibasaki, M.
    Org. Lett., 2018, 20, 308-311
  • "Bis(2-pyridyl)amides as Readily Cleavable Amides Under Catalytic, Neutral, and Room-Temperature Conditions"
    Adachi, S.; *Kumagai, N.; *Shibasaki, M.
    Synlett , 2018, 29, 301-305
  • "Catalytic enantioselective addition of diethyl phosphite to N-thiophosphinoyl ketimines: preparation of (R)-diethyl(1-amino-1-phenylethyl)phosphonate"
    Lin, S.; Otsuka, Y.; Yin, L.; *Kumagai, N.; *Shibasaki, M.
    Org. Synth., 2017, 94, 313-331
  • "Direct Catalytic Asymmetric Aldol Addition of an α-CF3 Amide to Arylglyoxal Hydrates"
    Matsuzawa, A.; Noda, H.; *Kumagai, N.; *Shibasaki, M.
    J. Org. Chem, 2017, 82, 8304–8308
  • "Photocatalytic α-Acylation of Ethers"
    Sun, Z.; *Kumagai, N; *Shibasaki, M.
    Org. Lett., 2017, 19, 3727–3730
  • "Direct Catalytic Asymmetric Aldol Addition of an α-CF3 Amide to Arylglyoxal Hydrates"
    Matsuzawa, A.; Noda, H.; Kumagai, N.; Shibasaki, M.
    J. Org. Chem., 2017, 82, 8304-8308
  • "Photocatalytic α-Acylation of Ethers"
    Sun, Z.; Kumagai, N.; Shibasaki, M.
    Org. Lett., 2017, 19, 3727-3730
  • "Direct N-Acylation of Sulfoximines with Carboxylic Acids Catalyzed by the B3NO2 Heterocycle"
    Noda. H.; Asada, Y.; Shibasaki, M.; Kumagai, N.
    Chem. Commun., 2017, 53, 7447-7450
  • "Cu/Pd Synergistic Dual Catalysis: Asymmetric α-Allylation of an α-CF3 Amide"
    Saito, A.; Kumagai, N.; Shibasaki, M.
    Angew. Chem., Int. Ed., 2017, 56, 5551-5555
  • "Catalytic Asymmetric Synthesis of CF3-Substituted Tertiary Propargylic Alcohols via Direct Aldol Reaction of α-N3 Amide"
    Noda, H.; Amemiya, F.; Weidner, K.; Kumagai, N.; Shibasaki, M.
    Chem. Sci., 2017, 8, 3260-3269
  • "Reversible Stereoselective Folding/Unfolding Fueled by the Interplay of Photoisomerism and Hydrogen Bonding"
    Opie, C. R.; Kumagai, N.; Shibasaki, M.
    Angew. Chem. Int. Ed., 2017, 56, 3349-3353
  • "Unique Physicochemical and Catalytic Properties Dictated by the B3NO2 Ring System"
    Noda, H.; Furutachi, M.; Asada, Y.; Shibasaki, M.; Kumagai, N.
    Nat. Chem., Advanced Online Publication, Advanced Online Publication, Advanced Online Publication
  • "Asymmetric Flow Catalysis: Mix-and-Go Solid-Phase Nd/Na Catalyst for Expeditious Enantioselective Access to a key Intermediate of AZD7594"
    Nonoyama, A.; Kumagai, N.; Shibasaki, M.
    Tetrahedron Lett., 2017, 73, 1517-1521
  • "Direct Catalytic Asymmetric Aldol Reaction of α-Alkylamides"
    Liu, Z.; Takeuchi, T.; Pluta, R.; Arteaga, F. A.; Kumagai, N.; Shibasaki, M.
    Org. Lett., 2017, 19, 710-713
  • "Catalytic Asymmetric Synthesis of 2,3,3,3-Tetrafluoro-2-Methyl-1-Arylpropan-1-Amines as Useful Building Blocks for SAR-Studies"
    Brewitz, L.; Kumagai, N.; Shibasaki, M.
    J. Fluor. Chem., 2017, 194, 1-7
  • "Enantioselective Synthesis of α,α-Disubstituted α-Amino Acids via Direct Catalytic Asymmetric Addition of Acetonitrile to α-Iminoesters"
    Lin, S.; Kumagai, N.; Shibasaki, M.
    Org. Biomol. Chem., 2016, 14, 9725-9730
  • "Preparation of Nd/Na Heterogeneous Catalyst from Bench-Stable and Inexpensive Nd Salt for an anti-Selective Catalytic Asymmetric Nitroaldol Reaction"
    Nonoyama, A.; Hashimoto, K.; Saito, A.; Kumagai, N.; Shibasaki, M.
    Tetrahedron Lett., 2016, 57, 1815-1819
  • "Direct Catalytic Asymmetric Mannich-Type Reaction of Alkylamides"
    Arteaga, F. A.; Liu, Z.; Brewitz, L.; Chen, J.; Sun, B.; Kumagai, N.; Shibasaki, M.
    Org. Lett., 2016, 18, 2391-2394
  • "Direct Catalytic Asymmetric Mannich-type Reaction of α,β-Unsaturated γ-Butyrolactam with Ketimines"
    Lin, S.; Kumagai, N.; Shibasaki, M.
    Chem. Eur. J., 2016, 22, 3296-3299
  • "Electrophilic Activation of α,β-Unsaturated Amides: Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated γ-Butyrolactones"
    Zhang, M.; Kumagai, N.; Shibasaki, M.
    Chem. Eur. J., 2016, 22, 5525-5529

Review

  • 「Synthetic Studies of Viridiofungins, Broad-Spectrum Antifungal Agents and Serine Palmitoyl Transferase Inhibitors」 Kumagai, N.; Shibasaki, M., J. Antibiot., 71, 53–59 , 10.1038/ja.2017.110
  • 「Strategic Immobilization of Molecular Catalysts onto Carbon Nanotubes via Noncovalent Interaction for Catalytic Organic Transformations」 Kumagai, N.; Shibasaki, M., Isr. J. Chem., Early View, Early View, Early View
  • 「Nucleophilic and Electrophilic Activation of Non-Heteroaromatic Amides in Atom-Economical Asymmetric Catalysis」 Kumagai, N.; Shibasaki, M., Chem. Eur. J., 22, 15192-15200, 2016
  • 「A Career in Catalysis: Masakatsu Shibasaki」 Kumagai, N.; Kanai, M.; Sasai, H., ACS Catal., 6, 4699-4709, 2016

Conference

  • ​4th International Symposium on Precisely Designed Catalysts with Customized Scaffolding
    "​Catalytic Function Dictated by the B3NO2 Ring System", Invited Lecture
    Naoya Kumagai
    12/3/2019~12/5/2019, 奈良, 日本
  • ​4th International Symposium on Precisely Designed Catalysts with Customized Scaffolding
    "TriQuinoline and Its O-Embedded Congeners", Poster Presentation
    Yuya Ota, Shinya Adachi, Masakatsu Shibasaki, Naoya Kumagai
    12/3/2019~12/5/2019, 奈良, 日本
  • ​27th International Society of Heterocyclic Chemistry Congress
    "Systematic Examination of Catalytic Amide Bond Formation by the Readily Accessible B3NO2 Heterocycle-Containing Molecule Pym-DATB ", Oral Presentation
    Christopher R. Opie, Hidetoshi Noda, Masakatsu Shibasaki, Naoya Kumagai
    9/1/2019~9/6/2019, 京都, 日本
  • ​27th International Society of Heterocyclic Chemistry Congress
    "​Enantioselective Photocatalysis with Unique 7-Azaindoline Auxiliaries — Opportunities and Challenges", Oral Presentation
    Santosh K. Pagire, Naoya Kumagai, Masakatsu Shibasaki
    9/1/2019~9/6/2019, 京都, 日本
  • University College London
    "​Chemistry Empowered by Unique Heterocycles.", Invited Lecture
    Naoya Kumagai
    7/4/2019~7/4/2019, London, England
  • MBLA Lecture Tour, University of California, Berkeley​
    "Chemistry Empowered by Unique Heterocycles ", Invited Lecture
    Naoya Kumagai
    10/23/2018~10/23/2018, Berkeley​, US
  • ​MBLA Lecture Tour, MIT
    "Chemistry Empowered by Unique Heterocycles ", Invited Lecture
    Naoya Kumagai
    10/18/2018~10/18/2018, Cambridge, US
  • ​MBLA Lecture Tour, ​Sunovion
    "Chemistry Empowered by Unique Heterocycles ", Invited Lecture
    Naoya Kumagai
    10/17/2018~10/17/2018, Marlborough, US
  • MBLA Lecture Tour,​ Harvard University
    "Chemistry Empowered by Unique Heterocycles ", Invited Lecture
    Naoya Kumagai
    10/16/2018~10/16/2018, Cambridge, US
  • MBLA Lecture Tour, ​Merck
    "​Chemistry Empowered by Unique Heterocycles", Invited Lecture
    Naoya Kumagai
    10/15/2018~10/15/2018, New Jersey, US
  • MBLA Lecture Tour, Princeton University
    "​Chemistry Empowered by Unique Heterocycles ", Invited Lecture
    Naoya Kumagai
    10/15/2018~10/15/2018, New Jersey, US
  • MBLA Lecture Tour, ​ETH Zurich
    "Chemistry Empowered by Unique Heterocycles ", Invited Lecture
    Naoya Kumagai
    10/12/2018~10/12/2018, Zurich, Switzerland
  • ​MBLA Lecture Tour, ​Max-Planck Institute
    "Chemistry Empowered by Unique Heterocycles ", Invited Lecture
    Naoya Kumagai
    10/10/2018~10/10/2018, Düsseldorf, Germany
  • ​MBLA Lecture Tour, ​Ludwig-Maximillians University
    "Chemistry Empowered by Unique Heterocycles ", Invited Lecture
    Naoya Kumagai
    10/8/2018~10/8/2018, München, Germany
  • ​University of Nottingham
    "Chemistry Empowered by Unique Heterocycles​", Invited Lecture
    Naoya Kumagai
    10/4/2018~10/4/2018, Nottingham, UK
  • ​University of Edinburgh
    "Chemistry Empowered by Unique Heterocycles ", Invited Lecture
    Naoya Kumagai
    10/3/2018~10/3/2018, Edinburgh, UK
  • CSJ-RSC Joint Symposium
    "Catalytic Function Dictated by the B3NO2 Heterocycle ", Oral Presentation
    Naoya Kumagai
    10/1/2018~10/1/2018, London, UK
  • The 1st Sino-Japanese Symposium on Catalysis for Precision Synthesis & Catalysis
    "Catalytic Function Dictated by the B3NO2 Ring System. ", Oral Presentation
    Naoya Kumagai
    5/27/2018~5/30/2018, Shanghai, China
  • RACI National Centenary Conference 2017
    "Reversible stereoselective folding/Unfolding fueled by the interplay of photoisomerism and hydrogen bonding", Oral Presentation
    Opie, C.; Kumagai, N.; Shibasaki, M.;
    7/23/2017~7/28/2017, Melbourne, Australia
  • ​16th International Meeting on Boron Chemistry(IMEBORON XVI)
    "​A B3NO2 Heterocyclic Catalyst for General Direct Amidation ", Oral Presentation
    Noda,H.; Furutachi, M.; Asada, Y.; Shibasaki, M.; Kumagai, N.
    7/9/2017~7/13/2017, Hong Kong, China
  • 18th Tetrahedron Symposium
    "​DATB catalysis: efficient catalytic direct amidation promoted by the B3NO2 heterocycle ", Poster Presentation
    Noda,H.; Furutachi, M.; Asada, Y.; Shibasaki, M.; Kumagai, N
    6/27/2017~6/30/2017, Budapest, Hungary
  • The19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis(OMCOS 19)、Korea
    "Asummetric α-Allylation of α-CF3 Amide Promoted by Cu/Pd Synergistic Catalyst", Poster Presentation
    Saito, A.; Kumagai, N.; Shibasaki, M.
    6/25/2017~6/29/2017, Jeju Island, Korea
  • The19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis(OMCOS 19)​
    "Asummetric α-Allylation of α-CF3 Amide Promoted by Cu/Pd Synergistic Catalyst", Poster Presentation
    Saito, A.; Kumagai, N.; Shibasaki, M.
    6/25/2017~6/29/2017, Jeju Island, Korea
  • The19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis(OMCOS 19)
    "Direct Catalytic Aldol Reaction of α-N3 Amide for the Asymmetric Synthesis of CF3-Substituted tertiary Propargylic Alcohols.", Oral Presentation
    Noda, H.; Amemiya, F.; Weidner, K.; Kumagai, N.; Shibasaki, M.
    6/25/2017~6/29/2017, Jeju Island, Korea
  • International Symposium on Pure and Applied Chemistry 2017 (ISPAC)
    "DATB Catalysis: Efficient Catalytic Direct Amidation Promoted by the B3NO2 Heterocycle", Oral Presentation
    Kumagai, N.
    6/8/2017~6/10/2017, Ho Chi Minh City, Vietnam
  • BOSS XV
    "Catalytic Generation of α-CF3 Enolate for Producing Chiral Building Blocks with CF3-Containing Stereogenicity", Poster Presentation
    Kumagai, N.; Brewitz, L.; Yin, L.; Matsuzawa, A.; Alagiri, K.; Arteaga, F. A.; Shibasaki, M.
    7/10/2016~7/15/2016, Antwerp, Belgium

National Conference

  • ​高砂香料株式会社 平塚研究所
    "​特殊ヘテロ環の化学", 招待講演
    熊谷直哉
    1/17/2020~1/17/2020, 平塚
  • ​第14回プロセス化学ラウンジ
    "​特殊ヘテロ環を駆使する触媒反応", 招待講演
    熊谷直哉
    11/29/2019~11/29/2019, 湯河原
  • ​19th Tateshina Conference
    "​TriQuinoline", 口頭発表
    Shinya Adachi, Masakatsu Shibasaki, Naoya Kumagai
    11/8/2019~11/9/2019, 茅野
  • 第45回反応と合成の進歩シンポジウム​
    "アセトニトリルのダイレクト型触媒的不斉付加反応", 口頭発表
    齊藤誠,熊谷直哉,柴崎正勝
    10/28/2019~10/29/2019, 倉敷
  • ​第45回反応と合成の進歩シンポジウム
    "Featuring New 7-Azaindolines Auxiliaries for the Enantioselective Photocatalytic Synthesis of GABA Derivatives", ポスター発表
    Santosh K. Pagire,熊谷直哉,柴崎正勝
    10/28/2019~10/29/2019, 倉敷
  • ​Otsu Conference
    "Chemistry Empowered by Unique Heterocycles", 招待講演
    Naoya Kumagai
    10/15/2019~10/16/2019, 大津
  • ​静岡県立大学
    "特殊ヘテロ環の化学", 招待講演
    熊谷直哉
    10/11/2019~10/11/2019, 静岡
  • 第30回基礎有機化学討論会
    "​一原子欠損グラフェンモデルトリキノリンの合成・物性解析", 口頭発表
    足立慎弥、柴崎正勝、熊谷直哉
    9/25/2019~9/27/2019, 大阪
  • ​日本化学会新領域研究グループ「分子空間化学」第4回研究集会
    "​TriQuinoline", 口頭発表
    熊谷直哉
    9/13/2019~9/13/2019, 京都
  • ​第29回光学活性シンポジウム
    "Chemistry Empowered by Unique Heterocycles.", 招待講演
    Naoya Kumagai
    6/1/2019~6/1/2019, 東京
  • 第17回次世代を担う有機化学シンポジウム
    "Direct Catalytic Asymmteic Aldol Reaction of α-Alkoxyamides to α-Fluorineated Ketones.", 口頭発表
    Roman Pluta, 熊谷直哉, 柴崎正勝
    5/31/2019~6/1/2019, 渋谷
  • 日本薬学会第139年会
    "Direct catalytic asymmetric Mannich-type reaction of an α -CF3 amide to isatin imines supported by mechanistic study on bis(tetrahydrophosphole)-type ligands", 口頭発表
    余 金生, *李 釗, 野田 秀俊, 熊谷 直哉, 柴﨑 正勝
    3/20/2019~3/23/2019, 幕張
  • 日本薬学会第139年会
    "​Achiral Trisubstituted Thioureas as Secondary Ligands to Cu(I) Catalysts: Direct Catalytic Asymmetric Addition of alpha-Fluoronitriles to Imines", 口頭発表
    Pandur BALAJI, Lennart BREWITZ, 熊谷 直哉, 柴崎 正勝
    3/20/2019~3/23/2019, 幕張
  • 日本薬学会第139年会
    "Direct Catalytic Asymmetric Aldol Reaction of Amides in the Synthesis of Fluorinated α, β-Dihydroxy Acids ", 口頭発表
    Roman PLUTA, 熊谷 直哉, 柴崎 正勝
    3/20/2019~3/23/2019, 幕張
  • ​日本薬学会第139年会
    "​新規C4N4フルオロフォア", 口頭発表
    野田 秀俊, 朝田 康子, 丸山 達朗, 滝沢 直己, 野田 展生, 柴﨑 正勝, 熊谷 直哉
    3/20/2019~3/23/2019, 幕張
  • ​日本薬学会第139年会
    "Lewis酸/光触媒系によるGABA誘導体の不斉合成法の開発", 口頭発表
    Santosh Kisan PAGIRE, 熊谷 直哉, 柴﨑 正勝
    3/20/2019~3/23/2019, 幕張
  • ​日本薬学会第139年会
    "​α-ケトエステルのanti選択的触媒的不斉ニトロアルドール反応", 口頭発表
    柄澤 智哉, Raphael ORIEZ, 熊谷 直哉, 柴﨑 正勝
    3/20/2019~3/23/2019, 幕張
  • ​日本化学会第99年会特別企画
    "Chemistry Empowered by Unique Heterocycles", 招待講演
    Naoya Kumagai
    3/16/2019~3/19/2019, 神戸
  • ​新学術領域研究「高難度物質変換反応の開発を指向した精密制御反応場の創出」第6回公開シンポジウム
    "B3NO2特殊ヘテロ環による触媒反応", 口頭発表
    熊谷直哉
    1/21/2019~1/22/2019, 京都
  • ​御茶ノ水女子大学講演
    "​特異ヘテロ環化合物の化学", 招待講演
    熊谷直哉
    9/26/2018~9/26/2018, 東京
  • ​第29回万有仙台シンポジウムMBLA受賞講演
    "アミドをPlayGroundとした反応設計", 招待講演
    熊谷直哉
    6/9/2018~6/9/2018, 仙台
  • 日本薬学会第138年会
    "不斉配位子―遷移金属触媒によるアルキルニトリル類のアルデヒド類への不斉付加反応の開発", ポスター発表
    大朏彰道、YoumeiBAO、ShaoquanLIN1、熊谷直哉、柴崎正勝
    3/25/2018~3/28/2018, 金沢
  • 日本薬学会第138年会
    "Catalytic Oligopeptide Synthesis", 口頭発表
    劉子建、野田秀俊、柴崎正勝、熊谷直哉
    3/25/2018~3/28/2018, 金沢
  • 日本薬学会第138年会
    "ピリミジン型DATB:簡便合成が可能なアミド化触媒", 口頭発表
    Christopher OPIE、野田秀俊、柴崎正勝、熊谷直哉
    3/25/2018~3/28/2018, 金沢
  • Catalytic Oligopeptide Synthesis
    "Catalytic Oligopeptide Synthesis", 口頭発表
    Liu, Z.; Noda, H.; Shibasaki, M.; Kumagai, N.
    11/20/2017~11/22/2017, 大阪
  • 第43回反応と合成の進歩シンポジウム
    "複核ホウ素ヘテロ環DATBの化学:直接的アミド化触媒への展開", 口頭発表
    Noda, H.; Furutachi, M.; Liu, Z. Asada, Y.; Shibasaki, M.; Kumagai, N.
    11/6/2017~11/7/2017, 冨山
  • 第66回高分子討論会
    "ホウ素含有複素環構造を有する有機分子触媒に対するモノクローナル抗体の作製(Preparation of Monoclonal Antibodies against an Organic Catalyst with Boron-containing Heterocycle Structure)", ポスター発表
    安達琢真, 野田秀俊, 柴崎正勝, 熊谷直哉, 山口浩靖 (Adachi, T.; Noda, H.; Shibasaki, M.; Kumagai, N.; Yamaguchii, H.)
    9/20/2017~9/22/2017, 松山
  • 第28回基礎有機化学討論会
    "周辺立体環境因子によるアミドの活性化", ポスター発表
    Adachi, S.; Kumagai, Kumagai, k.; Shibasaki, M.
    9/7/2017~9/9/2017, 福岡
  • 28th Symposium on Physical Organic Chemistry
    "​周辺立体環境因子によるアミドの活性化", 口頭発表
    Adachi, S.; Kumagai, N.; Shibasaki, M.
    9/7/2017~9/9/2017, 福岡
  • 第15回次世代を担う有機化学シンポジウム
    "α-Halo Amides as Competent Latent Enolates: Direct Catalytic Asymmetric Mannich-type Reaction", 口頭発表
    Sun,S.; Balaji, P.V.; Kumagai, N.; Shibasaki.M
    5/26/2017~5/27/2017, 渋谷
  • 第2回公開シンポジウム
    "分子認識による反応場制御", 口頭発表
    山口浩靖
    1/25/2017~1/26/2017, 名古屋
  • 新学術領域研究「精密制御反応場」第2回公開シンポジウム
    "アルキルニトリルの汎用炭素求核剤としての利用を可能にする新規触媒系の開拓", 口頭発表
    Kumagai, N.
    1/25/2017~1/26/2017, 名古屋
  • ITbM/IGER Chemistry Workshop 2016
    "アミドをPLAYGROUNDとした反応設計", 口頭発表
    Kumagai, N.
    12/19/2016~12/19/2016, 名古屋

Patent

  • 「触媒、アミド結合の形成方法、及びアミド化合物の製造方法」
    出願人:公益財団法人微生物化学研究会
    発明者:熊谷直哉,クリストファー オウピ,野田秀俊,柴崎正勝
    出願番号:2017-156990
  • 「触媒、アミド結合の形成方法、及びアミド化合物の製造方法」
    出願人:Hirota, K.; Yamashita, T.
    発明者:Kumagai, N.; Noda, H.; Furutachi, M.; Asada, Y.; Shibasaki, M.
    出願番号:JP2016-028596

Award

  • 「MBLA賞」
    受賞者:Kumagai Naoya
    贈呈元:公益財団法人 MSD生命科学財団
    受賞日:2/2/2018

Media

  • Chemical & Engineering News, 雑誌記事
    Noda, H.; Furutachi, M.; Asada, Y.; Shibasaki, M.; Kumagai, N., 12/2017
    PDF File
  • Phys Org, 雑誌記事
    Noda, H.; Furutachi, M.; Asada, Y.; Shibasaki, M.; Kumagai, N., 2/22/2017
    PDF File
  • 毎日新聞, 新聞
    Noda, H.; Furutachi, M.; Asada, Y.; Shibasaki, M.; Kumagai, N., 1/31/2017
    PDF File
  • 日経産業新聞, 新聞
    Noda, H.; Furutachi, M.; Asada, Y.; Shibasaki, M.; Kumagai, N., 1/31/2017
    PDF File
  • Chemical & Engineering News, 雑誌記事
    Noda, H.; Furutachi, M.; Asada, Y.; Shibasaki, M.; Kumagai, N., 1/30/2017
    PDF File