Grant-in-Aid for Scientific Research on Innovative AreasPrecise Formation of a Catalyst Having a Specified Field for Use in Extremely Difficult Substrate Conversion Reactions

Osami Shoji » Japanese

Affiliation Graduate School of Science, Nagoya University
Position Associate Professor
Contact Email
HP http://bioinorg.chem.nagoya-u.ac.jp/en/index.html
Keyword Heme proteins, Cytochrome P450, Decoy molecule
Institute "The Chemical Society of Japan", "Division of biofunctional chemistry, The Chemical Society of Japan", "Japan Society of Coordination Chemistry", "The Society of Polymer Science, Japan", "American Chemical Society"

Abstract

◆Research Topics:
Material Transformation Using Biocatalysts Assisted by External Additives

Achievement

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Original papers

  • "Crystals in Minutes: Instant On-Site Microcrystallisation of Various Flavours of the CYP102A1 (P450BM3) Haem Domain"
    Stanfield, J. K.; Omura, K.; Matsumoto, A.; Kasai, C.; Sugimoto, H.; Shiro, Y.; Watanabe, Y.; Shoji, O.
    Angew. Chem. Int. Ed., 2020, 59, 4611-7618
  • "Hoodwinking Cytochrome P450BM3 into Hydroxylatiing Non-Native Substrates by Exploiting Its Substrate Misrecognition"
    Shoji,O.; Aiba, Y.; Watanabe, Y.
    Acc. Chem. Res., 2019, 52(4), 925-934
  • "The effect of decoy molecules on the activity of the P450BM3 holoenzyme and a heme domain peroxygenase variant"
    Dezvarei,S.; Shoji, O.; Watanabe, Y.; Bell, S. G.
    Catalysis Communications, 2019, 124, 97-102
  • "Highly malleable haem-binding site of the haemoprotein HasA permits stable accommodation of bulky tetraphenylporphycenes"
    Sakakibara,E.; Shisaka,Y.; Iwai, Y.; Yamada, S.; Uehara, H.; Tosha, T.; Sugimoto, H.; Shiro, Y.; Stanfield, J. K.; Ogawa, K.; Watanabe, Y.; Shoji, O.
    RSC Advances, 2019, 9(32), 18697-18702
  • "Hijacking the Heme Acquisition System of Pseudomonas aeruginosa for the Delivery of Phthalocyanine as an Antimicrobial"
    Shisaka,Y.; Y. Iwai,Y.; Yamada, S.; Uehara, H.; Tosha, T.; Sugimoto, H.; Shiro, Y.; Stanfield, J. K.; Ogawa, K.; Watanabe, Y.; Shoji, O.
    ACS Chemical Biology, 2019, 14(7), 1637-1642
  • "Development of a High-Pressure Reactor Based on Liquid-Flow Pressurisation to Facilitate Enzymatic Hydroxylation of Gaseous Alkanes"
    Ariyasu, S.; Kodama, Y. (equal contribution); Kasai, C; Cong, Z.; Stanfield, J. K.; Aiba, Y.; Watanabe, Y.; Shoji, O.
    ChemCatChem, 2019, 11, 4709-4714
  • "Whole-Cell Biotransformation of Benzene to Phenol Catalysed by Intracellular Cytochrome P450BM3 Activated by External Additives"
    Karasawa,M;Stanfield,J.K;Yanagisawa,S;Shoji,O;Watanabe,Y.
    Angew. Chem. Int. Ed., 2018, 57, 12264-12269
  • "Reconstitution of Full-Length P450BM3 with an Artificial Metal Complex by Utilising the Transpeptidase Sortase A"
    Omura,K;Aiba,Y;Onoda,H;Stanfield,J.K;Ariyasu,S;Sugimoto,H;Shiro,Y;Shoji,O;Watanabe,Y.
    Chem. Commun., 2018, 54, 7892-7895
  • "Peptide Nucleic Acid Conjugated with Ru-complex Stabilizing Double-Duplex Invasion Complex Even under Physiological Conditions"
    Hibino,M;Aiba,Y;Watanabe,Y;Shoji,O.
    ChemBioChem, 2018, 19, 1601-1604
  • "Metabolic enhancement of 2,3´,4,4´,5-pentachlorobiphenyl (CB118) using cytochrome P450 monooxygenase isolated from soil bacterium under the presence of perfluorocarboxylic acids (PFCAs) and the structural basis of its metabolism"
    Goto,E;Haga,Y;Kubo,M;Itoh,T;Kasai,C;Shoji,O;Yamamoto,K;Matsumura,C;Nakano,T;Inui,H.
    Chemosphere, 2018, 210, 376-383
  • "Efficient hydroxylation of cycloalkanes by co-addition of decoy molecules to variants of the cytochrome P450 CYP102A1"
    Dezvarei, S.; Onoda, H.; Shoji, O.; Watanabe, Y.; Bell, S. G.
    Journal of Inorganic Biochemistry, 2018, 1, 1
  • "Dual‐Functional Small Molecules for Generating an Efficient Cytochrome P450BM3 Peroxygenase"
    Ma, N.; Chen, Z.; Chen, J.; Chen, J.; Wang, C.; Zhou, H.; Yao, L.; Shoji, O.; Watanabe, Y.; Cong, Z.
    Angew. Chem. Int. Ed., 2018, 57, 1-6
  • "Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate"
    Tosha, T.; Nomura, T.; Nishida, T.; Saeki, N.; Okubayashi, K.; Yamagiwa, R.; Sugahara, M.; Nakane, T.; Yamashita, K.; Hirata, K.; Ueno, G.; Kimura, T.; Hisano, T.; Muramoto, K.; Sawai, H.; Takeda, H.; Mizohata, E.; Yamashita, A.; Kanematsu, Y.; Takano, Y.; Nango, E.; Tanaka, R.; Nureki, O.; Shoji, O.; Ikemoto, Y.; Murakami, H.; Owada, S.; Tono, K.; Yabashi, M.; Yamamoto, M.; Ago, H.; Iwata, S.; Sugimoto, H.; Shiro, Y.; Kubo, M.
    Nature Communications, 2017, 8(1), 1585
  • "Inhibiting Aggregation of β-Amyloid by Folded and Unfolded Forms of Fimbrial Protein of Gram-Negative Bacteria"
    Yamamoto, K.; Oyaizu, M.; Takahashi, T.; Watanabe, Y.; Shoji, O.
    ChemistrySelect, 2017, 2(28), 9058-9062
  • "α-Oxidative decarboxylation of fatty acids catalysed by cytochrome P450 peroxygenases yielding shorter-alkyl-chain fatty acids"
    Onoda, H.; Shoji, O.; Suzuki, K.; Sugimoto, H.; Shiro, Y.; Watanabe, Y.
    Catal. Sci. Technol., 2018, 8(2), 434-442
  • "Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenyl-Porphyrin and Derivatives Thereof as an Artificial Prosthetic Group"
    Uehara, H.; Shisaka, Y.; Nishimura, T.; Sugimoto, H.; Shiro, Y.; Miyake, Y.; Shinokubo, H.; Watanabe, Y.; Shoji, O
    Angew. Chem. Int. Ed, 2017, 56, 15279-15283
  • "Control of Stereoselectivity of Benzylic Hydroxylation Catalysed by Wild-type Cytochrome P450BM3 Using Decoy Molecules"
    Suzuki, K.; Stanfield, J. K.; Shoji, O.; Yanagisawa, S.; Sugimoto, H.; Shiro, Y.; Watanabe, Y.
    Catal. Sci. Technol., 2017, 7, 3332-3338
  • "Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives "
    Shoji, O.; Yanagisawa, S.; Stanfield, J. K.; Suzuki, K.; Cong, Z.; Sugimoto, H.; Shiro, Y.; Watanabe, Y.
    Angew. Chem. Int. Ed., 2017, 56, 10324-10329
  • "A Substrate-Binding-State Mimic of H2O2-Dependent Cytochrome P450 Produced by One-point Mutagenesis and Peroxygenation of Non-native Substrates "
    Shoji, O.; Fujishiro, T.; Nishio, K.; Kano, Y.; Kimoto, H.; Chien, S.-C.; Onoda, H.; Muramatsu, A.; Tanaka, S.; Hori, A.; Sugimoto, H.; Shiro, Y.; Watanabe, Y.
    Catal. Sci. Tech, 2016, 6, 5806-5811
  • "Use of apomyoglobin to gently remove heme from a H2O2-dependent cytochrome P450 and allow its reconstitution"
    Chien, S.-C.; Shoji, O.; Morimoto, Y.; Watanabe, Y.
    New J. Chem., 2017, 41, 302-307
  • "Monooxygenation of Nonnative Substrates Catalyzed by Bacterial Cytochrome P450s Facilitated by Decoy Molecules"
    Shoji, O.; Watanabe, Y.
    Chemistry Letters, 2017, 46, 278-288
  • "Acetate anion-triggered peroxygenation of non-native substrates by wild-type cytochrome P450s"
    Onoda, H.; Shoji, O.; Watanabe, Y.
    Dalton Trans, 2015, 44, 15316-15323
  • "Improved oxidation of aromatic and aliphatic hydrocarbons using rate enhancing variants of P450Bm3 in combination with decoy molecules"
    Munday, S. D.; Shoji, O.; Watanabe, Y.; Wong, L.-L.; Bell, S. G.
    Chem. Commun., 2016, 52, 1036-1039

Review

  • 「シトクロムP450BM3 の誤作動状態を利用したガス状アルカンの直接水酸化」 有安真也、愛場雄一郎、荘司長三, えねるみくす(日本エネルギー学会機関誌), 9, 147-154, 2, 2020
  • 「気体資源の有効活用を目指した高圧反応装置の開発」 有安真也、荘司長三, 月刊機能材料, 40, 46-56, 3, 2020
  • 「擬似基質による酵素活性化と高難度酸化反応」 荘司長三, 化学と生物, 56, 621-626, 9, 2018
  • 「酸化酵素の誤作動を利用するバイオ触媒開発」 荘司長三, 石油学会ペトロテック, Vol.41, P390, No.4, 2018
  • 「鉄の取り込みを阻害する新しい抗菌薬の開発」 四坂勇磨、荘司長三, 感染症, 48, 18-21, 5, 2018

Conference

  • 2nd China-Japan Joint Symposium on the Biosynthesis of Natural Products
    "Hydroxylation of Non-native Substrates Catalyzed by Cytochrome P450BM3 with Decoy Moleculues", Invited Lecture
    Shoji,O.
    1/14/2019~1/15/2019, Guangzhou, China
  • The 13th International Symposium on Organic Reactions
    "Hydroxylation of Nonnative Substrates Catalyzed by Wild-type Cytochrome P450BM3 with Decoy Molecules", Invited Lecture
    Shoji,O.
    11/21/2018~11/24/2018, Hsinchu, Taiwan
  • FHI-JST Joint Symposium“Current Topics and Challenges for Innovative Catalysts”
    "Hydroxylation of Non-native Substrates Catalyzed by Cytochrome P450BM3 Facilitated by Decoy Moleculues", Oral Presentation
    Shoji,O.
    10/31/2018~11/2/2018, Berlin, Germany
  • 43rd International Conference on Coordination Chemistry (ICCC2018)
    "Heme Acquisition Protein HasA with 5,15-Diphenylporphyrin and Its Derivatives as an Artificial Prosthetic Group", Oral Presentation
    Shoji,O;Shisaka,Y;Uehara,H;Nishimura,T;Miyake,Y;Shinokubo,H;Sugimoto,H;Shiroe,Y;Watanabe,Y.
    7/30/2018~8/4/2018, Miyagi, Japan
  • Cytochrome P450 Biodiversity & Biotechnology 2018
    "Developing the P450BM3-Based Whole-Cell Biocatalyst for the Direct Hydroxylation of Benzene to Phenol Activated by Decoy Molecules", Poster Presentation
    Karasawa,M;Yanagisawa,S;Shoji,O;Watanabe,Y.
    7/15/2018~7/19/2018, York, UK
  • Cytochrome P450 Biodiversity & Biotechnology 2018
    "Post-translational Ligation of Haem and Reductase Domains of CYP102A1(P450BM3) Mediated by Transpeptidase Sortase A; Investigation on Catalytic Properties of Manganese-substituted P450BM3", Poster Presentation
    Omura,K;Aiba,Y;Ariyasu,S;Onoda,H;Sugimoto,H;Shiro,Y;Shoji,O;Watanabe,Y.
    7/15/2018~7/19/2018, York, UK
  • Cytochrome P450 Biodiversity & Biotechnology 2018
    "Enzymatic Oxidation of Methane by Cytochrome P450BM3 Variants with Decoy Molecules under High Pressure Condition", Poster Presentation
    Ariyasu,S;Cong,Z;Shoji,O;Aiba,Y;Kasai,C;Onoda,H;Suzuki,K;Sugimoto,H;Shiro,Y;Kamachi,T;Yoshizawa,K;Watanabe,Y.
    7/15/2018~7/19/2018, York, United Kingdom
  • Tenth International Conference on Porphyrins and Phthalocyanines (ICPP-10)
    "Incorporation of Synthetic Metal Complexes into Heme Acquisition Proteins of Pseudomonas aeruginosa", Poster Presentation
    Sakakiara,E;Shisaka,Y;Shoji,O;Sugimoto,H;Watanabe,Y.
    7/1/2018~7/6/2018, Munich, Germany
  • Tenth International Conference on Porphyrins and Phthalocyanines (ICPP-10)
    "Development of Stereoselective Oxidation System Catalyzed by Cytochrome P450BM3 Using Decoy Molecules", Poster Presentation
    Suzuki,K;Shoji,O;Stanfield,J.K;Yanagisawa,S;Sugimoto,H;Shiro,Y;Watanabe,Y.
    7/1/2018~7/6/2018, Munich, Germany.
  • Tenth International Conference on Porphyrins and Phthalocyanines (ICPP-10), July 1-6, 2018, .
    "Selective Sterilization of Pseudomonas aeruginosa Utilizing Phthalocyanine Captured by the Heme-Acquisition Protein HasA", Poster Presentation
    Shisaka,Y;Iwai,Y;Yamada,S;Tosha,T;Sugimoto,H;Shiro,Y;Watanabe,Y;Shoji,O.
    7/1/2018~6/6/2018, Munich, Germany
  • Tenth International Conference on Porphyrins and Phthalocyanines (ICPP-10)
    "Heme Acquisition Protein HasA with Metal-Phthalocyanine and 5,15-DiphenylporphyrinDerivatives as an Artificial Prosthetic Group", Oral Presentation
    Shoji,O;Uehara,H;Shisaka,Y;Nishimura,T;Miyake,Y;Shinokubo,H;Sugimoto,H;Shiro,Y;Watanabe,Y.
    7/1/2018~7/6/2018, Munich, Germany
  • 3rd Japan - UK Joint Symposium on Coordination Chemistry,Apr.30-May 2,2018,
    "Hydroxylation of Nonnative Substrates Catalyzed by Cytochrome P450BM3 Assisted by Decoy Molecules", Invited Lecture
    Shoji,O.
    4/30/2018~5/2/2018, St Andrews, UK
  • 255thACS National Meeting & Exposition
    "Switchable stereoselectivity in monooxygenation of non-native substrates by P450BM3 using decoy molecules", Poster Presentation
    Suzuki,K.:Shoji,O.:Stanfield,J.:Sugimoto,H.:Shiro,Y.:Watanabe,Y.
    3/18/2018~3/22/2018, New Orleans, LA, USA
  • 255thACS National Meeting & Exposition
    "Reconstitution of self-sufficient cytochrome P450 with artificial metal complexes", Poster Presentation
    Omura,K.:Aiba,Y.:Ariyasu,S.:Shoji,O.:Sugimoto,H.:Shiro,Y.:Watanabe,Y.
    3/18/2018~3/22/2018, New Orleans, LA, USA
  • 255thACS National Meeting & Exposition
    "Hydroxylation of gaseous alkanes and benzene catalyzed by cytochrome P450BM3 using decoy molecules as a substrate analogue", Oral Presentation
    Shoji,O.: Watanabe,Y
    3/18/2018~3/25/2018, New Orleans, LA, USA
  • 11th Japan-China Joint Symposium on Metal Cluster Compounds
    "Hydroxylation of Nonnative Substrate Catalyzed by Cytochrome P450BM3 using Decoy Molecules", Invited Lecture
    O. Shoji
    10/7/2017~10/10/2017, Nagoya, Japan
  • The 2nd Japan-US Bilateral Meeting on Coordination Chemistry
    "Nonnative Substrate Hydroxylation Catalyzed by Cytochrome P450BM3 without any Mutagenesis", Invited Lecture
    O. Shoji
    9/15/2017~9/16/2017, Sapporo, Japan
  • HALCHEM VIII
    "Use of the malfunction of cytochrome P450BM3 induced by decoy molecules with an aromatic ring for the propane hydroxylation", Poster Presentation
    D. Nakamura, Z. Cong, K. Komoda, H. Amii, O. Shoji, Y. Watanabe
    9/12/2017~9/15/2017, INUYAMA, JAPAN
  • 第2回精密制御反応場国際シンポジウム( 2nd International Symposium on Precisely Designed Catalysts with Customized Scaffolding )
    "Development of Biocatalysts for Extremely Difficult Oxidation Reactions", Invited Lecture
    O. Shoji
    5/12/2017~5/13/2017, 吹田, 日本
  • the 5th Symposium on Advanced Biological Inorganic Chemistry (SABIC-2017)
    "Gaseous Alkane Hydroxylation Catalyzed by Cytochrome P450BM3 Assisted by Next Generation Decoy Molecules ", Keynote Lecture
    O. Shoji
    1/7/2017~1/12/2017, Kolkata, India
  • AsBIC8
    "Growth Inhibition of Pseudomonas Aeruginosa by Hasa with Synthetic Metal Complexes and A Novel Elimination System of Bacteria by Photo-Irradiation", Invited Lecture
    O. Shoji, C. Shirataki, Y. Shisaka, H. Uehara, Y. Iwai, A. Nakashima, M. Terada, S. Ozaki, H. Sugimoto, Y. Shiro, Y. Watanabe
    12/4/2016~12/9/2016, Auckland, Newzealand
  • Japan-Korea-Taiwan Bioinorganic Chemistry Symposium (日韓台生物無機化学シンポジウム)
    "Non-native Substrate Hydroxylation catalyzed by Cytochrome P450s Utilizing False Recognition of Target Substrates ", Invited Lecture
    O. Shoji
    9/29/2016~9/30/2016, Okazaki, Japan
  • 錯体化学会第66回討論会シンポジウム
    "Construction of Biocatalysts Based on Substrate Misrecognition of Enzymes ", Invited Lecture
    O. Shoji
    9/10/2016~9/12/2016, Fukuoka, Japan
  • Japan-Australia Joint Symposium on Coordination Chemistry (JAJSCC2016)
    "Hydroxylation of Non-Native Substrates by Tricking the Substrate Recognition of Cytochrome P450s ", Invited Lecture
    O. Shoji
    9/8/2016~9/10/2016, Fukuoka, Japan
  • SeleCa Workshop on Artificial Metalloenzymes
    "Gaseous Alkane Hydroxylation by Cytochrome P450s Assisted by Decoy Molecules ", Invited Lecture
    O. Shoji
    9/5/2016~9/5/2016, Aachen, Germany
  • FOR 1405 Symposium with external guests at the RWTH Aachen University
    "Gaseous alkane hydroxylation by tricking the substrate recognition of cytochrome P450s ", Invited Lecture
    O. Shoji
    9/1/2016~9/3/2016, Aachen, Germany
  • Pacifichem 2015
    "Activation of cytochrome P450BM3 by decoy molecules for gaseous alkane hydroxylation", Invited Lecture
    O. Shoji, Y. Watanabe
    12/15/2015~12/20/2015, Honolulu, Hawaii, USA
  • BIOTRANS2015
    "Hydroxylation of Gaseous Alkanes Catalyzed By Cytochrome P450BM3 Triggered By Decoy Molecules", Invited Lecture
    O. Shoji, Y. Watanabe
    7/26/2015~7/30/2015, Vienna, Austria
  • ICBIC17
    "Growth inhibition of Pseudomonas aeruginosa by HasA with metal-phthalocyanine and a novel elimination system of bacteria by photo-irradiation", Invited Lecture
    O. Shoji, C. Shirataki, Y. Iwai, A. Nakashima, M. Terada, S. Ozaki, H. Sugimoto, Y. Shiro, Y. Watanabe
    7/20/2015~7/24/2015, Beijing, China

National Conference

  • 日本化学会第99春季年会(2019)
    "シトクロムP450BM3の誤作動を引き起こすペプチド様分子の網羅的スクリーニング", 口頭発表
    米村開、有安真也、ジョシュア・カイル・スタンフィールド、小野田浩宜、杉本宏、城宜嗣、荘司長三、渡辺芳人
    3/16/2019~3/19/2019, 神戸
  • New Frontier in Protein Design & Engineering
    "Hydroxylation of Nonnative Substrates Catalyzed by Cytochrome P450BM3 Facilitated by Decoy Molecules", 招待講演
    2) Osami Shoji
    3/15/2019~3/16/2019, 愛知
  • 日本におけるケミカルバイオロジーの新展開第189委員会 平成30年度 第4回定例会
    "酸化酵素の誤作動を誘起する低分子化合物による基質特異性変換", 招待講演
    荘司長三
    3/6/2019~3/6/2019, 大阪市
  • 分子研研究会「錯体化学を基盤とした階層構造制御と機能発現」
    "酸化酵素の誤作動を誘起する擬似基質を用いる物質変換", 招待講演
    荘司長三
    3/3/2019~3/4/2019, 愛知
  • 日本化学会第99春季年会
    "5,15-ジアザポルフィリン鉄錯体のsp3 C-H酸化触媒としての利用", 口頭発表
    西村 翼・渡辺 芳人・荘司 長三・忍久保 洋・三宅 由寛
    3/2019~3/2019, 神戸
  • Core-to-Core Symposium “Elements Function for Transformative Catalysis and Materials”
    "Hydroxylation of Non-native Substrates Catalyzed by Cytochrome P450BM3 Activated by External Additives", 招待講演
    Osami Shoji
    2/7/2019~2/8/2019, 名古屋大学
  • 新学術領域研究「高難度物質変換反応の開発を指向した精密制御反応場の創出」第6回公開シンポジウム
    "金属蛋白質の対象誤認識を利用する機能改変", 招待講演
    荘司長三
    1/21/2019~1/22/2019, 京都市
  • 新学術「生合成リデザイン」第5回公開シンポジウム
    "金属酵素の誤作動を利用する物質変換", 招待講演
    荘司長三
    12/15/2018~12/16/2018, 千葉市
  • 酵素工学研究会第80回講演会
    "酸化酵素の誤作動を利用する物質変換", 招待講演
    荘司長三
    11/16/2018~11/16/2018, 東京
  • 第49回中部化学関係学協会支部連合秋季大会
    "ベンゼンをフェノールに変換するバイオ触媒系の開発", 招待講演
    荘司長三
    11/3/2018~11/4/2018, 名古屋市
  • 第12回バイオ関連化学シンポジウム
    "擬似基質を用いる基質特異性変換", 口頭発表
    荘司長三・唐澤昌之・鈴木和人・Joshua Stanfield・大村慧太・愛場雄一郎・有安真也・杉本宏・城宜嗣・渡辺芳人
    9/9/2018~9/11/2018, 大阪
  • 新化学技術推進協会(JACI)主催講演会
    "偽物の基質による酵素の誤作動を利用する物質変換", 招待講演
    荘司長三
    8/23/2018~8/23/2018, 東京
  • The 68th Conference of Japan Society of Coordination Chemistry
    "Heme Acquisition Protein HasA with Synthetic Metal Complexes as an Artificial Prosthetic Group", 口頭発表
    Shoji,O;Shisaka,Y;Uehara,H;Yamada,S;Sugimoto,H;Shiro,Y;Nishimura,T;Shinokubo,H;Miyake,Y;Watanabe,Y
    7/28/2018~7/30/2018, Miyagi
  • 東京大学大学院薬学系研究科天然物化学教室セミナー
    "生体触媒の基質誤認識を利用する高難度水酸化反応", 招待講演
    荘司長三
    5/18/2018~5/18/2018, 東京
  • 日本化学会 第98春季年会 (2018)
    "緑膿菌のヘム獲得タンパク質を用いた新規殺菌法の開発", ポスター発表
    吉村麻実、愛場雄一郎、荘司長三、渡辺芳人
    3/20/2018~3/23/2018, 船橋
  • 日本化学会 第98春季年会 (2018)
    "緑膿菌のヘム輸送蛋白質複合体PhuUV-Tに関する研究", 口頭発表
    榊原 えりか、四坂 勇磨、荘司 長三、杉本宏、渡辺 芳人
    3/20/2018~3/23/2018, 船橋
  • 日本化学会 第98春季年会 (2018)
    "緑膿菌のヘム獲得タンパク質を用いた新規殺菌法の開発", 口頭発表
    吉村麻実、愛場雄一郎、荘司長三、渡辺芳人
    3/20/2018~3/23/2018, 船橋
  • 日本化学会 第98春季年会 (2018)
    "緑膿菌のヘム獲得システムを利用した光線力学的殺菌法の開発", 口頭発表
    山田志歩、四坂勇磨、岩井佑介、荘司長三、渡辺芳人
    3/20/2018~3/23/2018, 船橋
  • 日本化学会 第98春季年会 (2018)
    "高度好熱菌由来Argonauteタンパク質への人工核酸の取り込みと効率的なDNA切断", 口頭発表
    山口華苗、愛場雄一郎、荘司長三、渡辺芳人
    3/20/2018~3/23/2018, 船橋
  • 日本化学会 第98春季年会 (2018)
    "効果的なインベージョン複合体形成に向けたペプチド核酸(PNA)の開発", ポスター発表
    中森祥哉、愛場雄一郎、荘司長三、渡辺芳人
    3/20/2018~3/23/2018, 船橋
  • 日本化学会 第98春季年会 (2018)
    "効果的なインベージョン複合体形成に向けたペプチド核酸(PNA)の開発", 口頭発表
    中森祥哉、愛場雄一郎、荘司長三、渡辺芳人
    3/20/2018~3/23/2018, 船橋
  • 日本化学会 第98春季年会 (2018)
    "Ru錯体修飾PNAの高効率なInvasionと光活性評価", 口頭発表
    日比野柾、愛場雄一郎、荘司長三、渡辺芳人
    3/20/2018~3/23/2018, 船橋
  • 日本化学会 第98春季年会 (2018)
    "Analyzing the mechanism of growth inhibition against Pseudomonas aeruginosa using heme acquisition protein HasA with synthetic metal complexes", 口頭発表
    Shisaka,Y.:Shoji,O.:Uehara,H.:Iwai,Y.:Nakashima,A.:Watanabe,Y.
    3/20/2018~3/23/2018, 船橋
  • 日本化学会 第98春季年会 (2018)
    "シトクロムP450が触媒する菌体内芳香族水酸化反応の外部添加因子による活性化", ポスター発表
    唐澤昌之、荘司長三、渡辺芳人
    3/20/2018~3/22/2018, 船橋
  • 日本化学会 第98春季年会 (2018)
    "シトクロムP450が触媒する菌体内芳香族水酸化反応の外部添加因子による活性化", 口頭発表
    唐澤昌之、荘司長三、渡辺芳人
    3/20/2018~3/22/2018, 船橋
  • 日本化学会 第98春季年会 (2018)
    "Analyzing Degradation Mechanism of Fatty Acid to The Next Shorter Fatty Acid Using Hydrogen Peroxide Activated by Cytochrome P450 Peroxygenase", 口頭発表
    Onoda,H.:Shoji,O.:Suzuki,K.:Sugimoto,H.:Shiro,Y.:Watanabe,Y.
    3/20/2018~3/22/2018, 船橋
  • 日本化学会 第98春季年会 (2018)
    "Hydroxylation of small gaseous alkane by mutated cytochrome P450BM3 with decoy molecules", 口頭発表
    Ariyasu,S.:Shoji,O.:Aiba,Y.:Sugimoto,H.:Shiro,Y.:Watanabe,Y.
    3/20/2018~3/23/2018, 船橋
  • 日本化学会 第98春季年会 (2018)
    "芳香環を有する新規デコイ分子によるシトクロムP450BM3の誤作動誘起を用いたガス状アルカンの水酸化", 口頭発表
    中村大介、荘司長三、森内敏之、杉本宏、城宜嗣、網井秀樹、渡辺芳人
    3/20/2018~3/23/2018, 船橋
  • 第7回名古屋大学シンクロトロン光研究センターシンポジウム
    "疑似基質による酸化酵素の誤作動誘起と高難度水酸化反応", 口頭発表
    荘司長三、小野田浩宜、元川竜平、中川洋、渡辺芳人
    1/19/2018~1/19/2018, 名古屋
  • 第50回酸化反応討論会
    "疑似基質による酸化酵素の高活性化と不活性アルカン類の水酸化", 口頭発表
    荘司長三、有安真也、鈴木和人、中村大、唐澤昌之、愛場雄一、渡辺芳人
    11/11/2017~11/12/2017, 横浜
  • 50周年記念プレシンポジウム~CREST・さきがけ「革新的触媒」メタン資源利用に向けて~
    "疑似基質による酵素活性化とメタン水酸化", 口頭発表
    荘司長三
    11/10/2017~11/10/2017, 横浜
  • 第57回オーロラセミナー
    "疑似基質による生体触媒の誤作動誘起と高難度酸化反応", 招待講演
    荘司長三
    7/23/2017~7/24/2017, 北海道上川郡東神楽町
  • 第63回高分子研究発表会(神戸)
    "シトクロムP450導入高分子ゲルにおける酵素活性制御", ポスター発表
    小原健司、小野田浩宜、荘司長三、山口浩靖
    7/14/2017~7/14/2017, 神戸
  • 第27回金属の関与する生体関連反応シンポジウム(SRM2017)
    "芳香環を有する疑似基質を用いたシトクロムP450BM3の誤作動誘起とプロパンの水酸化反応", ポスター発表
    中村大介、叢 志奇、小茂田和希、網井秀樹、荘司長三、渡辺芳人
    6/16/2017~6/17/2017, 東京
  • 第2回公開シンポジウム
    "分子認識による反応場制御", 口頭発表
    山口浩靖
    1/25/2017~1/26/2017, 名古屋

Media

  • Chemistry Letters, カバーピクチャ
    O. Shoji, Y. Watanabe, 3/5/2017
    PDF File
  • Catalysis Science & Technology, カバーピクチャ
    O. Shoji, T. Fujishiro, K. Nishio, Y. Kano, H. Kimoto, S. Chien, H. Onoda, A. Muramatsu, S. Tanaka, A. Hori, H. Sugimoto, Y. Shiro, Y. Watanabe, 8/7/2016
    PDF File

conference _management

  • 「第66回高分子討論会」
    国内会議, 特定テーマ セッションオーガナイザー, 9/20/2017~9/22/2017, 松山, 日本