Grant-in-Aid for Scientific Research on Innovative AreasPrecise Formation of a Catalyst Having a Specified Field for Use in Extremely Difficult Substrate Conversion Reactions

Hiroyasu Yamaguchi » Japanese

Affiliation Graduate School of Science, Osaka University
Position Professor
Contact Email
HP http://www.chem.sci.osaka-u.ac.jp/lab/yamaguchi/english/index.html
Speciality Bio-related polymers
Keyword Antibody / Molecular recognition / Non-covalent bond / Specificity
Institute CSJ SPSJ

Abstract

Creation of novel hybrid catalysts by introducing a transition metal complex into an antigen binding site of monoclonal antibody

Achievement

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Original papers

  • "Control of Microenvironment around Enzymes by Hydrogels"
    Kobayashi, Y.; Kohara, K.; Kiuchi, Y.; Onoda, H.; Shoji, O.; Yamaguchi, H.
    Chem. Commun., 2020, 56, in press
  • "Palladium-Catalyst Stabilized in Chiral Environment of Monoclonal Antibody in Water"
    Kobayashi, Y.; Murata, K.; Harada, A.; Yamaguchi, H.
    Chem. Commun., 2020, 56, 1605-1607
  • "Mechanical Properties of Supramolecular Polymeric Materials Cross-Linked by Donor‒Acceptor Interactions"
    Itano, M.; Kobayashi, Y.; Takashima, Y.; Harada, A.; Yamaguchi, H.
    Chem. Commun., 2019, 55, 3809-3812
  • "Development of Atroposelective Antibodies by Immunization with a Racemic Mixture of Binaphthyl Derivatives"
    Adachi, T.; Harada, A.; Yamaguchi, H.
    Bull. Chem. Soc. Jpn., 2019, 92(9), 1462-1466
  • "Self-Healing and Shape-Memory Properties of Polymeric Materials Cross-Linked by Hydrogen Bonding and Metal–Ligand Interactions"
    Kobayashi, Y.; Hirase, T.; Takashima, Y.; Harada, A.; Yamaguchi H.
    Polym. Chem., 2019, 10(33), 4519-4523
  • "Atroposelective Antibodies as a Designed Protein Scaffold for Artificial Metalloenzymes"
    Adachi, T.; Harada, A.; Yamaguchi, H.
    Sci. Rep., 2019, 9, 13551
  • "Mechanical Properties of Supramolecular Polymeric Materials Cross-Linked by Donor‒Acceptor Interactions"
    Itano, M.; Kobayashi, Y.; Takashima, Y.; Harada, A.; Yamaguchi H.
    Chem. Commun., 2019, 55, 3809-3812
  • "Solvent-Free Photoresponsive Artificial Muscles Rapidly Driven by Molecular Machines"
    Ikejiri, S.; Takashima, Y.; Osaki M.; Yamaguchi H.; Harada, A.
    J. Am. Chem. Soc. , 2018, 140, 17308-17315
  • "Control of the Threading Ratio of Cyclic Molecules in Polyrotaxane Consisting of Poly(ethylene glycol) and a-Cyclodextrins"
    Kobayashi, Y.; Nakamitsu, Y.; Zheng, Y.; Takashima, Y.; Yamaguchi, H.; Harada, A.
    Chem. Commun., 2018, 54, 7066-7069
  • "Toward a Translational Molecular Ratchet: Face-Selective Translation Coincident with Deuteration in a Pseudo-Rotaxane"
    Hashidzume, A.; Kuse, A.; Oshikiri, T.; Adachi, S.; Okumura, M.; Yamaguchi, H.; Harada, A.
    Sci. Rep., 2018, 8, 8950
  • "Visible Chiral Discrimination via Macroscopic Selective Assembly"
    Zheng, Y.; Kobayashi, Y.; Sekine, T.; Takashima, Y.; Hashidzume, A.; Yamaguchi, H.; Harada, A.
    Commun. Chem. , 2018, 1, 4
  • "Visible Chiral Discrimination via Macroscopic Selective Assembly"
    Zheng, Y.; Kobayashi, Y.; Sekine, T.; Takashima, Y.; Hashidzume, A.; Yamaguchi, H.;*Harada, A.
    Communications Chemistry , 2018, 1(1), 4
  • "Supramolecular Materials Cross-Linked by Host–Guest Inclusion Complexes: The Effect of Side Chain Molecules on Mechanical Properties"
    Takashima, Y.; Sawa, Y.; Iwaso, K.; Nakahata, M.; Yamaguchi, H.;*Harada, A.
    Macromolecules, 2017, 50, 3254-3261
  • "Visualization of Chiral Binaphthyl Recognition by Atroposelective Antibodies with Thermoresponsive Polymers"
    Odaka, T.; Adachi, T.; Harada, A.;*Yamaguchi, H.
    Chemistry Letters , 2017, 46, 1173-1175
  • "Movable Cross-Linked Polymeric Materials from Bulk Polymerization of Reactive Polyrotaxane Cross-Linker with Acrylate Monomers"
    Koyanagi, K.; Takashima, Y.; Yamaguchi, H.;*Harada, A.
    Macromolecules, 2017, 50, 5695-5700
  • "Multifunctional Stimuli-Responsive Supramolecular Materials with Stretching, Coloring, and Self-Healing Properties Functionalized via Host–Guest Interactions"
    Takashima, Y.; Yonekura, K.; Koyanagi, K.; Iwaso, K.; Nakahata, M.; Yamaguchi, H.;*Harada, A.
    Macromolecules , 2017, 50, 4144-4150
  • "Direct Adhesion of Dissimilar Materials Using Sonogashira Cross-coupling Reaction"
    Sekine, T.; Takashima, Y.; Yamaguchi, H.;*Harada, A.
    Chem. Lett., 2016, 45(11), 1250-1252
  • "Radical Polymerization by a Supramolecular Catalyst: Cyclodextrin with a RAFT Reagent"
    Koyanagi, K.; Takashima, Y.; Nakamura, T.; Yamaguchi, H.;*Harada, A.
    Beilstein J. Org. Chem., 2016, 12, 2495–2502
  • "Direct Chiral Separation of Binaphthyl Derivatives Using Atroposelective Antibodies"
    Adachi, T.; Odaka, T.; Harada, A.;*Yamaguchi, H.
    ChemistrySelect, 2017, 2(9), 2622–2625
  • "Manual Control of Catalytic Reactions: Reactions by an Apoenzyme Gel and a Cofactor Gel"
    Kobayashi, Y,: Takashima, Y.; Hashidzume, A.; Yamaguchi, H.;*Harada, A.
    Scientific Reports, 2015, 5, 16254

Books

  • 「生体機能高分子錯体」
    山口浩靖
    「機能高分子金属錯体」, 三共出版, 2020, 第3章

Conference

  • The 16th Pacific Polymer Conference (PPC16)
    "Creation of Multi-Functional Soft Materials by Introducing Plural Interaction Units", Invited Lecture
    Yamaguchi, H.
    12/8/2019~12/12/2019, Singapore, Singapore
  • The 2nd Japan Germany Singapore Trilateral Symposium on Precision Synthesis and Catalysis and 4th International Symposium on Precisely Designed Catalysts with Customized Scaffolding
    "Utilization of Monoclonal Antibodies as an Asymmetric Reaction Field to Synthesize Spiro Compounds", Poster Presentation
    Shiinara, M.; Uchida, M.; Kobayashi, Y.; Yamaguchi, H.
    12/2/2019~12/5/2019, Nara, Japan
  • The 2nd World Summit on Advances in Science, Engineering and Technology (INDIANA SUMMIT-2019)
    "Functionalization of Supramolecular Complexes by Hybridization of Transition Metal Complexes with Biomolecules", Plenary Lecture
    Yamaguchi, H.
    10/3/2019~10/5/2019, Indianapolis, USA
  • The 12th SPSJ International Polymer Conference (IPC2018)
    "Chiral Sensing, Separation and Further Functionalization with Monoclonal Antibodies", Poster Presentation
    Adachi, T.; Odaka, T.; Harada, A.; Yamaguchi, H.
    12/4/2018~12/7/2018, Hiroshima, Japan
  • The 12th SPSJ International Polymer Conference (IPC2018)
    "Photoinduced Electron Transfer between Porphyrin Derivative and Methylviologen under the Existence of Polyvinylpyrrolidone", Poster Presentation
    Cao, Y.; Takasaki, T.; Takashima, Y.; Yamaguchi, H.
    12/4/2018~12/7/2018, Hiroshima, Japan
  • 28th Anniversary World Congress on Biosensors
    "Chiral Sensing for Binaphthyl Derivatives with Monoclonal Antibodies", Poster Presentation
    Yamaguchi, H.; Adachi, T.; Harada, A.
    6/12/2018~6/15/2018, Miami, USA
  • The 8th International Symposium on Polymer Chemistry (PC2018)
    "Visible Chiral Discrimination via Macroscopic Selective Assembly", Poster Presentation
    Zheng, Y.; Kobayashi, Y.; Sekine, T.; Takashima, Y.; Hashidzume, A.; Yamaguchi, H.; Harada, A.
    6/6/2018~6/9/2018, Changchun, China
  • International Symposium on Polymer Chemistry 2018 (PC2018)
    "Hybrid Supramolecular Catalysts with Monoclonal Antibodies", Invited Lecture
    Yamaguchi, H.
    6/6/2018~6/9/2018, Changchun, China
  • The 2nd International Symposium on Biofunctional Chemistry (ISBC2017)
    "Chiral Recognition of Monoclonal Antibodies for Binaphthyl Derivatives", Poster Presentation
    Yamaguchi, H.; Adachi, T.; Odaka, T.; Harada, A.
    12/14/2017~12/16/2017, 京都府宇治市, 日本
  • The 2nd International Symposium on Biofunctional Chemistry (ISBC2017)
    "Supramolecular Complexes of Transition Metal Complexes with Monoclonal Antibodies as Asymmetric Catalysts", Poster Presentation
    Yamaguchi, H.; Mutrata, K.
    12/14/2017~12/16/2017, 京都府宇治市, 日本
  • 6th Gratama Workshop on Chemical Sciences and Innovation for a Sustainable Society
    "Functionalization of Supramolecular Complexes by Hybridization of Transition Metal Complexes with Monoclonal Antibodies", Invited Lecture
    Yamaguchi, H.
    10/29/2017~10/31/2017, University of Groningen (Groningen), The Netherlands
  • IUPAC 17th International Symposium on MacroMolecular Complexes
    "Direct Chiral Separation of Binaphthyl Derivatives Using Atroposelective Antibodies", Poster Presentation
    Adachi, T.; Odaka, T.; Harada, A.; Yamaguchi, H.
    8/28/2017~8/31/2017, 東京, 日本
  • IUPAC 17th Interna/onal Symposium on MacroMolecular Complexes (MMC-17)
    "Functionalization of Supramolecular Complexes by Hybridization of Transition Metal Complexes with Biomolecules", Invited Lecture
    Yamaguchi, H.
    8/28/2017~8/31/2017, 東京, 日本
  • The 11th SPSJ International Polymer Conference (IPC2016)
    "Monoclonal Antibodies with Chiral Recognition Ability for Binaphthol Derivatives", Poster Presentation
    Adachi, T.; Harada, A.; Yamaguchi, H.
    12/13/2016~12/16/2016, 福岡, 日本
  • ACP-2016-Korea
    "Functionalization of Supramolecular Complexes by Hybridization of Transition Metal Complexes with Biomolecules", Poster Presentation
    Yamaguchi, H.; Harada, A.
    10/27/2016~10/30/2016, Daejeon, Korea
  • 7th International Symposium on Polymer Chemistry (PC2016)
    "Control of Enzymatic Reactions with Apoenzyme- and Cofactor-Gels", Invited Lecture
    Yamaguchi, H.; Kobayashi, Y.; Takashima, Y.; Hashidzume, A.; Harada, A.
    9/7/2016~9/10/2016, Changchun, China
  • 20th International Symposium on Homogeneous Catalysis (ISHC XX Kyoto 2016)
    "Manual Control of Catalytic Reactions: Reactions by Apoenzyme- and Cofactor-Gels", Poster Presentation
    Yamaguchi,H.; Kobayashi,Y.; Takashima,Y.; Hashidzume,A.; Harada,A.
    7/11/2016~7/15/2016, 京都, 日本
  • 10th ISMSC-2015
    "Polymerization Mediated by RAFT Agents Bearing Cyclodextrin Moieties for Monomer Inclusion", Poster Presentation
    Koyanagi, K.; Takashima, Y.; Yamaguchi, H.; Harada, A.
    6/28/2015~7/2/2015, Strasbourg, France

National Conference

  • 第68回高分子討論会
    "Control of Photoinduced Electron Transfer by the Complex Formation of Water-Soluble Porphyrin with Polyvinylpyrrolidone", 口頭発表
    *Cao, Y.; Takasaki, T.; Takashima, Y.; Yamaguchi, H.
    9/25/2019~9/27/2019, 福井市
  • 日本化学会第99春季年会
    "Preparation of Antibodies for a Hoveyda-Grubbs Catalyst", ポスター発表
    Okabayashi, S.; Takashima, Y.; Matsuo, T.; Yamaguchi, H.
    3/16/2019~3/19/2019, 神戸
  • 日本化学会第99春季年会
    "Fixation of Hoveyda-Grubbs-type complexes onto biomolecules through ligand exchange(2):Ligand Exchange on proteins and peptides", 口頭発表
    Jatmika, C.; Goshima, K.; Hirota, S.; Yamaguchi, H.; Matsuo, T.
    3/16/2019~3/19/2019, 神戸
  • 日本化学会第99春季年会
    "Monoclonal Antibodies as a Designed Protein Scaffold for Chiral Separation and Asymmetric Catalysis", 口頭発表
    Adachi, T.; Odaka, T.; Harada, A.; Yamaguchi, H.
    3/16/2019~3/19/2019, 神戸
  • 高分子学会九州支部フォーラム
    "生体高分子の認識能を利用 した機能性超分子錯体の創製", 招待講演
    山口浩靖
    2/23/2018~2/23/2018, 熊本県熊本市
  • 平成29年度日本素材物性学会研究会
    "超分子錯体が形成する特異的反応場", 招待講演
    山口浩靖
    12/8/2017~12/8/2017, 秋田県秋田市
  • 第11回バイオ関連化学シンポジウム
    "Control of Photoinduced Electron Transfer Using Polymers Specific to Porphyrins", ポスター発表
    Yamaguchi, H.; Takasaki, T.
    9/7/2017~9/9/2017, 東京
  • 第66回高分子学会年次大会
    "ポリビニルピロドン添加によるフィからオゲ誘導体への光誘起電子移動の制御", ポスター発表
    高崎友絵、池田憲昭、中村亮介、濱田格雄、高島義徳、山口浩靖
    5/29/2017~5/31/2017, 幕張
  • 第66回高分子学会年次大会
    "温度応答性高分子を用いたヘム酵素の反応制御", ポスター発表
    牧野早恵、高島義徳、山口浩靖
    5/29/2017~5/31/2017, 幕張
  • 日本農芸化学会2017年度大会(京都)
    "生体高分子と遷移金属錯体からなる超分子の機能化", 招待講演
    山口浩靖
    3/17/2017~3/19/2017, 京都
  • 日本化学会第97春季年会
    "Synthesis of a Hoveyda-Grubbs Catalyst for Introducing into Protein with Cysteine Residues", ポスター発表
    Wakabayashi, K.; Matsuo, T.; Hirota, S. Yamaguchi, H.
    3/16/2017~3/19/2017, 慶應義塾大学(神奈川県横浜市)
  • 日本化学会 第97春季年会 (2017)
    "スピロ化合物に対するモノクローナル抗体の作製", ポスター発表
    内田雅之、谷本郁、穴田仁洋、松永茂樹、山口浩靖
    3/16/2017~3/19/2017, 横浜(日吉)
  • 第2回公開シンポジウム
    "分子認識による反応場制御", 口頭発表
    山口浩靖
    1/25/2017~1/26/2017, 名古屋
  • 第1回産総研・阪大 先端フォト二クス・バイオセンシング OIA ワークショップ
    "抗体の超分子形成を利用した特異的バイオセンシング", 招待講演
    山口浩靖
    8/18/2016~8/18/2016, 吹田市
  • 第16 回日本蛋白質科学会
    "生体高分子に遷移金属錯体を導入したハイブリッド触媒の創製", 招待講演
    山口浩靖, 小林裕一郎、高島義徳、橋爪章仁、原田明
    6/7/2016~6/9/2016, 福岡
  • 日本化学会第96春季年会
    "Purification of Chiral Binaphthyl Derivatives Using Monoclonal Antibodies", ポスター発表
    Adachi, T.; Odaka, T.; Takashima, Y.; Yamaguchi, H.; Harada, A.
    3/24/2016~3/27/2016, 京田辺
  • 第64回高分子討論会
    "Characterization and Functionalization of Monoclonal Antibodieswith Chiral Recognition Ability for Binaphthol Derivatives", 口頭発表
    Adachi, T.; Odaka, T.; Yamaguchi, H.; Harada, A.
    9/15/2015~9/17/2015, 仙台

Award

  • 「Poster Award」
    受賞者:Adachi, T.; Yamaguchi, H.
    贈呈元:IUPAC (17th International Symposium on MacroMolecular Complexes)
    受賞日:8/30/2017
  • 「The 4th Presidential Awards for Encouragement, Osaka University」
    受賞者:Yamaguchi, H.
    贈呈元:Osaka University
    受賞日:7/2015

Media

  • Polymer Chemistry (RSC), カバーピクチャ
    「Highlighting research results from Osaka University, Osaka, Japan」
    Yamaguchi, H. Harada, A., 6/2019
    RSC雑誌における当研究室の研究成果紹介
    PDF File
  • Chemistry Letters, 化学と工業, その他
    「Editor’s Choice」
    Odaka, T.; Adachi, T.; Harada, A.; Yamaguchi, H., 8/2017
    Editor’s Choice
  • ChemistrySelect, カバーピクチャ
    「Cover Picture: (ChemistrySelect 09/2017) (page 2621)」
    Adachi, T.; Odaka, T.; Harada, A.; Yamaguchi, H., 3/24/2017
    The cover picture shows how optical isomers can be separated with high enantiopurity. A procedure for chiral separation based on the difference in the molecular weights of the antigen-antibody complex and analyte is developed. Atroposelective monoclonal antibodies (mAbs) were successfully isolated. Unlike chromatographic methods, the high molecular recognition ability of mAb can separate enantiomers with a one-step physical event. The large difference in the molecular weights between the analyte and mAbs realizes the separation of the free analyte by ultrafiltration. In addition, both enantiomers can be obtained by a simple one-step procedure where mAbs are prepared for each enantiomer. More information can be found in the Communication by Adachi et al. (DOI: 10.1002/slct.201700231).
    PDF File

conference _management

  • 「日本化学会第99春季年会(2019)」
    国内会議, プログラム委員会委員長, 3/16/2019~3/19/2019, 神戸, 日本
  • 「6th Gratama Workshop on Chemical Sciences and Innovation for a Sustainable Society」
    国際会議, Scientific Organizing Committee, 10/29/2017~10/31/2017, Groningen, The Netherlands
  • 「第66回高分子討論会」
    国内会議, 特定テーマ セッションオーガナイザー, 9/20/2017~9/22/2017, 松山, 日本

outreach

  • イベント参加・出展
    山口 浩靖, オープンキャンパスでの研究紹介, 大阪大学理学部
    大阪, 日本, 8/8/2019~8/8/2019
  • イベント参加・出展
    山口 浩靖, オープンキャンパスでの研究紹介, 大阪大学理学部
    大阪, 日本, 8/9/2018~8/9/2018
  • 一般向け講演会・セミナー
    山口浩靖, 講演者、公園題目「生体分子と遷移金属錯体からなる超分子錯体の機能化」, 群馬大学
    群馬県桐生市, 日本, 6/15/2017~6/16/2017
  • 小・中・高向け授業・実験・実習
    山口浩靖, 小学生サイエンススクールでの講演・実験, 大阪大学理学部
    豊中市, 日本, 8/22/2016~8/22/2016
  • 一般向け講演会・セミナー
    山口浩靖, 奈良先端科学技術大学院大学でのセミナー講演, NAIST
    奈良, 日本, 12/19/2016~12/19/2016
  • 一般向け講演会・セミナー
    山口浩靖, 「化学・高分子コロキウム講演会」での講演, 大阪大学理学部
    豊中市, 日本, 6/27/2016~6/27/2016