Grant-in-Aid for Scientific Research on Innovative AreasPrecise Formation of a Catalyst Having a Specified Field for Use in Extremely Difficult Substrate Conversion Reactions

Yoshihiro Sohtome » Japanese

Affiliation Synthetic Organic Chemistry Laboratory, RIKEN
Position Senior Research Scientist
HP http://soc.riken.jp/index-e.html
Speciality Synthetic Organic Chemistry, Asymmetric Catalysis, Chemical Biology
Keyword Transition metal, metal centrochirality, asymmetric catalysis, molecular oxygen, protein methylation
Institute The Chemical Society of Japan, The Pharmaceutical Society of Japan, The Society of Synthetic Organic Chemistry Japan, American Chemical Society, The Kinki Chemical Society Japan, Japanese Society for Chemical Biology

Abstract

Centrochiral transition metal complexes for catalytic asymmetric reactions

Achievement

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Original papers

  • "Cross-Coupling Reaction of Dimer-Derived Persistent Tertiary- Carbon-Centered Radicals with Azo Compounds"
    Ohnishi, R.; Sugawara, M.; Akakabe, M.; Ezawa, T.; Koshino, H.; Sohtome, Y.; Sodeoka, M.
    Asian J. Org. Chem. , 2019, 8, 1017-1023
  • "Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses"
    Sohtome, Y.; Shimazu, T.; Barjau, J.; Fujishiro, S.; Akakabe, M.; Terayama, N.; Dodo, K.; Ito, A.
    Yoshida, M.; Shinkai, Y.; *Sodeoka, M.
    Chem. Commun., 2018, 54, 9202-9205
  • "Naked d-orbital in a centrochiral Ni(II) complex as a catalyst for asymmetric [3+2] cycloaddition"
    *Sohtome, Y.; Nakamura, G.; Muranaka, A.; *Hashizume, D.; Lectard, S.; Tsuchimoto, T.; Uchiyama, M.; *Sodeoka, M.
    Nat. Commun., 2017, 8, 14875
  • "Catalytic Enantioselective [3+2] Cycloaddition of α‐Keto Ester Enolates and Nitrile Oxides"
    Bartlett, S. L.; *Sohtome, Y.; Hashizume, D.; White, P. S.; Sawamura, M.; *Johnson, J. S.; *Sodeoka, M.
    J. Am. Chem. Soc., 2017, 139, 8661-8666

Review

  • 「Multiselective Catalytic Asymmetric Reactions Using alpha-Keto Esters as Pronucleophiles」 *Sohtome, Y. *Sodeoka, M., Synlett, 30, in press
  • 「Design of the chiral environment for catalytic asymmetric acid-base catalysis」 *Sohtome Y.; *Nagasawa, K. *Sodeoka, M, Designed Molecular Space in Material Science and Catalysis, ---, 91-121, 2018
  • 「Development of Chaetocin and S-Adenosylmethionine Analogues as Tools for Studying Protein Methylation 」 Yoshihiro Sohtome, *Mikiko Sodeoka, Chem. Rec., 18, 1660-1671, 2018

Conference

  • RIKEN Epigenetics in Yokohama 2020 "Recent Advances in Plant Episcience and Epigenome Manipulation"
    "Chemical Protein Methylome Analyses Using ProSeAM", ポスター発表
    Yoshihiro Sohtome, Tadahiro Shimazu, Mai Akakabe, Yoichi Shinkai, Mikiko Sodeoka
    2/25/2020~2/26/2020, Yokohama, Japan
  • 4th International Symposium on Precisely Designed Catalysts with Customized Scaffolding
    "Cross-Coupling of Persistent Tertiary Carbon-Centered Radicals with Azo Compounds", ポスター発表
    Yoshihiro Sohtome, Rikako Ohnishi, Masumi Sugawara, Mai Akakabe, Tetsuya Ezawa, Hiroyuki Koshino, Mikiko Sodeoka
    12/3/2019~12/5/2019, Nara, Japan
  • 27th International Society of Heterocyclic Chemistry Congress (ISHC)
    "Catalytic Asymmetric [3+2] Cycloadditions With alpha-Keto Ester Enolates", 口頭発表
    Yoshihiro Sohtome, Mikiko Sodeoka
    9/1/2019~9/6/2019, Kyoto, Japan
  • University of Amsterdam: Lecture tour, JSPS program, “Precisely Designed Catalysts with Customized Scaffolding" in 2018
    "Controlling chiral environments constructed by molecular catalysts and enzymes", Invited Lecture
    Yoshihiro Sohtome
    9/14/2018~9/14/2018, Amsterdam, Netherlands
  • University of Groningen: Lecture tour, JSPS program, “Precisely Designed Catalysts with Customized Scaffolding" in 2018
    "Controlling chiral environments constructed by molecular catalysts and enzymes", Invited Lecture
    Yoshihiro Sohtome
    9/13/2018~9/13/2018, Groningen, Netherlands
  • Philipps-Universität Marburg: Lecture tour, JSPS program, “Precisely Designed Catalysts with Customized Scaffolding" in 2018
    "Controlling chiral environments constructed by molecular catalysts and enzymes", Invited Lecture
    Yoshihiro Sohtome
    9/7/2018~9/7/2018, Marburg, Germany
  • RWTH Aachen University: Lecture tour, JSPS program, “Precisely Designed Catalysts with Customized Scaffolding" in 2018
    "Controlling chiral environments constructed by molecular catalysts and enzymes", Invited Lecture
    Yoshihiro Sohtome
    9/6/2018~9/6/2018, Aachen, Germany
  • Justus-Liebig-Universitaẗ: Lecture tour, JSPS program, “Precisely Designed Catalysts with Customized Scaffolding" in 2018
    "Controlling chiral environments constructed by molecular catalysts and enzymes", Invited Lecture
    Yoshihiro Sohtome
    9/4/2018~9/4/2018, Gessen, Germany

National Conference

  • The 99th CSJ Annual Meeting
    "Strategies to control chiral environments constructed by molecular catalysts and enzymes", 招待講演
    Yoshihiro Sohtome
    3/16/2019~3/19/2019, Kobe