Grant-in-Aid for Scientific Research on Innovative AreasPrecise Formation of a Catalyst Having a Specified Field for Use in Extremely Difficult Substrate Conversion Reactions

Ryo Yazaki » Japanese

Affiliation Graduate School of Pharmaceutical Sciences, Kyushu University
Position Assistant Professor
Speciality Synthetic Organic Chemistry
Keyword Chemoselective Catalysis, Enantioselective Catalysis
Institute The Pharmaceutical Society of Japan, The Society of Synthetic Organic Chemistry, Japan


Development of Chemoselective Sterically Congested Cross Coupling Reaction


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Original papers

  • "Amino Acid Schiff Base Bearing Benzophenone Imine as a Platform for Highly Congested Unnatural -Amino Acid Synthesis"
    Yohei Matsumoto, Jun Sawamura, Yumi Murata, Takashi Nishikata,* Ryo Yazaki,* Takashi Ohshima*
    J. Am. Chem. Soc. , 2020, 142, 8498-8505
  • "Chemoselective Catalytic α-Oxidation of Carboxylic Acids: Iron/Alkali Metal Cooperative Redox Active Catalysis"
    Tanaka, Tsukushi, *Ryo Yazaki, *Takashi Ohshima
    J. Am. Chem. Soc., 2020, 142, 4517-4524
  • "Thionoesters as 1,2-Dipolarophiles for [4+2] Cycloaddition with Cyclobutanones"
    Yohei Matsumoto, Taro Tsuji, Daiki Nakatake, *Ryo Yazaki, *Takashi Ohshima
    Asian J. Org. Chem., 2019, 8, 1071-1074
  • "Mechanistic Insight into Catalytic Aerobic Chemoselective -Oxidation of Acylpyrazoles"
    Seiya Taninokuchi, *Ryo Yazaki, *Takashi Ohshima
    Heterocycles, 2019, 99, 906-918
  • "Chemoselective Catalytic Dehydrogenative Cross Coupling of 2-Acylimidazoles: Mechanistic Investigations and Synthetic Scope"
    Tsukushi Tanaka, Kayoko Hashiguchi, Takafumi Tanaka, *Ryo Yazaki, *Takashi Ohshima
    ACS Catal., 2018, 8, 8430-8440
  • "Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homocoupling Dimer"
    Takafumi Tanaka, Tsukushi Tanaka, Taro Tsuji, *Ryo Yazaki, *Takashi Ohshima
    Org. Lett., 2018, 20, 3541-3544
  • "An Expeditious Route to trans-Configured Tetrahydrothiophenes Enabled by Fe(OTf)3-Catalyzed [3+2] Cycloaddition of Donor-Acceptor Cyclopropanes with Thionoesters"
    Yohei Matsumoto, Daiki Nakatake, *Ryo Yazaki, *Takashi Ohshima
    Chem. Eur. J. , 2018, 24, 6062-6066
  • "Catalytic Aerobic Chemoselective α-Oxidation of Acylpyrazoles en Route to α-Hydroxy Acid Derivatives"
    Seiya Taninokuchi, *Ryo Yazaki, *Takashi Ohshima
    Org. Lett. , 2017, 19, 3187-3190
  • "Catalytic Chemoselective Conjugate Addition of Amino Alcohols to α,β-Unsaturated Ester; Hydroxy Group over Amino Group and Conjugate Addition over Transesterification"
    Zhao Li, Masamichi Tamura, *Ryo Yazaki, *Takashi Ohshima
    Chem. Pharm. Bull., 2017, 65, 19-21
  • "Chemo- and Regioselective Direct Functional Groups Installation through Catalytic Hydroxy Group-Selective Conjugate Addition of Amino Alcohols to α,β-Unsaturated Sulfonyl Compounds"
    Zhao Li, *Ryo Yazaki, *Takashi Ohshima
    Org. Lett., 2016, 18, 3350-3353


  • 「Recent strategic advances for the activation of benzylic C–H bonds for the formation of C–C bonds」 *Ryo Yazaki, *Takashi Ohshima, Tetrahedron Lett., 60, 151225, 2019
  • 「Cross-Dehydrogenative Coupling of Carbonyls for Heterocycle Synthesis」 *Ryo Yazaki, *Takashi Ohshima, Springer Nature in “Heterocycles via Cross Dehydrogenative Coupling: synthesis and functionalization", chapter 6, 213-229, 2019


  • The 2nd Japan Germany Singapore Trilateral Symposium on Precision Synthesis and Catalysis and 4th International Symposium on Precisely Designed Catalysts with Customized Scaffolding
    "Chemoselective Catalytic α-Oxidation of Carboxylic Acids", Poster Presentation
    Tsukushi Tanaka, Ryo Yazaki, Takashi Ohshima
    12/2/2019~12/5/2019, Nara, Japan
  • 27th International Society of Heterocyclic Chemistry Congress (ISHC-27)
    "Acylpyrazole as Carboxylic Acid Equivalent Platform for Chemoselective Catalysis", Poster Presentation
    Ryo Yazaki, Seiya Taninokuchi, Keisuke Tokumasu, Tsukushi Tanaka and Takashi Ohshima
    9/1/2019~9/6/2019, Kyoto, Japan
  • The 14th International Kyoto Conference on New Aspects of Organic Chemistry
    "Chemoselective Catalytic Dehydrogenative Cross Coupling of 2-Acylimidazoles", Poster Presentation
    Ryo Yazaki, Tsukushi Tanaka, Kayoko Hashiguchi, Takafumi Tanaka, Takashi Ohshima
    11/12/2018~11/16/2018, Kyoto, Japan
  • KU–NTU Joint International Symposium on Pharmaceutical Sciences
    "Chemoselective Oxidative Cross-Enolate Coupling", Oral Presentation
    Ryo Yazaki
    3/5/2018~3/5/2018, Fukuoka, Japan

National Conference

  • 第66回有機金属化学討論会
    "Sterically Congested Cross Coupling Reaction for Amino Acid Synthesis", 口頭発表
    Ryo Yazaki, Yohei Matsumoto, Jun Sawamura, Yumi Murata, Takashi Nishikata, and Takashi Ohshima
    9/14/2019~9/19/2019, 東京
  • 新学術領域研究「精密制御反応場」 第7回公開シンポジウム
    "立体障害型クロスカップリング反応によるアミノ酸合成", 口頭発表
    5/16/2019~5/17/2019, 仙台
  • 第14回IoLセンターコロキウム
    "化学選択性の精密制御のための触媒反応設計", 招待講演
    12/21/2018~12/21/2018, 宇部
  • 第44回反応と合成の進歩シンポジウム
    "2ーアシルイミダゾールの化学選択的な触媒的脱水素型クロスカップリング反応", ポスター発表
    11/5/2018~11/6/2018, 熊本
  • 第60回天然有機化合物討論会
    "アシルピラゾールをカルボン酸等価体プラットフォームとする化学選択的触媒反応 ", ポスター発表
    9/26/2018~9/28/2018, 久留米
  • 第2回産総研化学研究シンポジウム
    "化学選択性の精密制御のための触媒反応設計", 招待講演
    10/12/2018~10/12/2018, つくば
  • 日本化学会第98春季年会
    "Chemoselective Oxidative Cross-Enolate Coupling", 口頭発表
    Yazaki Ryo, Tanaka Takafumi, Tanaka Tsukushi, Ohshima Takashi
    3/20/2018~3/23/2018, 千葉
  • 第64回有機金属化学討論会
    "Catalytic chemoselective oxidative cross-enolate coupling Reaction", 口頭発表
    Ryo Yazaki, Takafumi Tanaka, Tsukushi Tanaka and Takashi
    9/7/2017~9/9/2017, 宮城県
  • 日本薬学会第137年会(仙台)一般シンポジウム:精密制御反応場が拓く有機合成化学の最前線
    "化学選択性の精密制御のための触媒反応設計", 口頭発表
    矢崎 亮
    3/24/2017~3/27/2017, 仙台
  • 有機合成化学協会九州山口支部講演会平成28年度有機合成化学講演会
    "Direct Catalytic Chemoselective α-Amination of Acylpyrazoles: A Concise Route to Unnatural α-Amino Acid Derivatives", 口頭発表
    矢崎 亮
    11/17/2016~11/17/2016, 福岡


  • 「平成28年度有機合成化学協会九州・山口支部優秀論文賞」
    受賞者:矢崎 亮
    贈呈元:公益財団法人 有機合成化学協会九州・山口支部


  • Synfacts 2016, 1206, 雑誌記事
    Daiki Nakatake, Ryo Yazaki, Yoshimasa Matsushima, Takashi Ohshima, 11/2016
    PDF File
  • 化学工業日報, 新聞
    Rikiya Horikawa, Chika Fujimoto, Ryo Yazaki, Takashi Ohshima, 6/27/2016
    PDF File
  • 日刊工業新聞, 新聞
    Daiki Nakatake, Ryo Yazaki, Yoshimasa Matsushima, Takashi Ohshima, 6/10/2016
    PDF File
  • 化学工業日報, 新聞
    Daiki Nakatake, Ryo Yazaki, Yoshimasa Matsushima, Takashi Ohshima, 6/3/2016
    PDF File