文部科学省 新学術領域研究(平成27年~31年)高難度物質変換反応の開発を指向した精密制御反応場の創出

河内 卓彌 » English

所属 慶應義塾大学理工学部化学科
役職 准教授
連絡先 Email
HP http://www.chem.keio.ac.jp/department/staff/detail_30.html
専門分野 有機金属化学、有機合成化学、錯体化学、高分子合成化学
研究キーワード 金属触媒・チェーンウォーキング・不斉触媒反応・sp3 C–H官能基化
所属学会・研究会 日本化学会、有機合成化学協会、高分子学会、アメリカ化学会

概要

精密反応場を利用したチェーンウォーキングを経る不活性炭素-水素結合の不斉官能基化

研究業績

印刷用ページを開く

原著論文

  • "Carbon–Carbon Bond Formation via Catalytically Generated Aminocarbene Complexes: Rhodium‐Catalyzed Hydroaminative Cyclization of Enynes with Secondary Amines"
    Takano, S.; Shiomi, R.; Morimoto, Y.; Kochi, T.; Kakiuchi, F.
    Angew. Chem. Int. Ed., 2020, , accepted
  • "Catalytic, Directed C–C Bond Functionalization of Styrenes"
    Onodera, S.; Togashi, R.; Ishikawa, S.; Kochi, T.; Kakiuchi, F.
    J. Am. Chem. Soc., 2020, 142(16), 7345-7349
  • "Efficient synthesis of 3,6,13,16-tetrasubstituted-tetrabenzo[a,d,j,m]coronenes by selective C–H/C–O arylations of anthraquinone derivatives"
    Terai, S.; Sato, Y.; Kochi, T.; Kakiuchi, F.
    Beilstein J. Org. Chem., 2020, 16, 544-550
  • "In Situ Generation of Ruthenium Carbonyl Phosphine Complexes as a Versatile Method for Development of Enantioselective C-O Bond Arylation"
    Kondo, H.; Kochi, T.; Kakiuchi, F.
    Chem. Eur. J., 2020, 26(8), 1737-1741
  • "Selective Monoarylation of Aromatic Ketones via C-H Bond Cleavage by Trialkylphosphine Ruthenium Catalysts"
    Suzuki, I.; Kondo, H.; Kochi, T.; Kakiuchi, F.
    J. Org. Chem., 2019, 84(20), 12975-12982
  • "Iron‐Catalyzed ortho-selective C-H Alkylation of Aromatic Ketones with N-Alkenylindoles and Partial Indolylation via 1,4-Iron Migration"
    Kimura, N.; Kochi, T.; Kakiuchi, F.
    Asian. J. Org. Chem., 2019, 8(7), 1115-1117
  • "Synthesis of N-Arylpyrazoles by Palladium-Catalyzed Coupling of Aryl Triflates with Pyrazole Derivatives"
    Onodera, S.; Kochi, T.; Kakiuchi, F.
    J. Org. Chem., 2019, 84(10), 6508-6515
  • "Metal-Catalyzed Sequential Formation of Distant Bonds in Organic Molecules: Palladium-Catalyzed Hydrosilylation/Cyclization of 1,n‐Dienes via Chain Walking"
    Kochi, T.; Ichinose, K.; Shigekane, M.; Hamasaki, T.; Kakiuchi, F.
    Angew. Chem. Int. Ed., 2019, 58(16), 5261-5265
  • "Selective Long-Distance Isomerization of Terminal Alkenes via Nondissociative Chain Walking"
    Yamasaki, Y.; Kumagai, T.; Kanno, S.; Kakiuchi, F.; Kochi, T.
    J. Org. Chem., 2018, 83(16), 9322-9333
  • "Direct Alkenylation of Allylbenzenes via Chelation-Assisted C-C Bond Cleavage"
    Onodera, S.; Ishikawa, S.; Kochi, T.; Kakiuchi, F.
    J. Am. Chem. Soc., 2018, 140(31), 9788-9792
  • "Palladium-Catalyzed C-H Iodination of N-(8-Quinolinyl)benzamide Derivatives Under Electrochemical and Non-Electrochemical Conditions"
    Sano, K.; Kimura, N.; Kochi, T.; Kakiuchi, F.
    Asian J. Org. Chem., 2018, 7(7), 1311-1314
  • "Iron-Catalyzed Regioselective Anti-Markovnikov Addition of C−H Bonds in Aromatic Ketones to Alkenes"
    Kimura, N.; Kochi, T.; Kakiuchi, F.
    J. Am. Chem. Soc., 2017, 139(42), 14849-14852
  • "Synthesis of Fluorine-Containing Tetraarylanthracenes via Ruthenium-Catalyzed C–O or C–F Arylation and their Crystal Structures"
    Izumoto, A.; Kondo, H.; Kochi, T.; Kakiuchi, F.
    Synlett, 2017, 28(19), 2609-2613
  • "Formation of α-Monosubstituted Propargylamines from Terminal Alkynes and Secondary Amines Using a (PNO)Rh/Cu Tandem Catalyst System"
    Takano, S.; Kochi, T.; Kakiuchi, F.
    Chem. Lett., 2017, 46(11), 1620-1623
  • "Palladium-Catalyzed ortho-Selective C–H Chlorination of Benzamide Derivatives under Anodic Oxidation Conditions"
    Konishi, M.; Tsuchida, K.; Sano, K.; Kochi, T.; Kakiuchi, F.
    J. Org. Chem., 2017, 82(16), 8716-8724
  • "Synthesis of Dibenzo[h,rst]pentaphenes and Dibenzo[fg,qr]pentacenes by the Chemoselective C-O Arylation of Dimethoxyanthraquinones"
    Suzuki, Y.; Yamada, K.; Watanabe, K.; Kochi, T.; Ie, Y.; Aso, Y.; Kakiuchi, F.
    Org. Lett., 2017, 19(14), 3791-3794
  • "Selective Monoarylation of Aromatic Ketones and Esters via Cleavage of Aromatic Carbon-Heteroatom Bonds by Trialkylphosphine Ruthenium Catalysts"
    Kondo, H.; Kochi, T.; Kakiuchi, F.
    Org. Lett., 2017, 19(4), 794-797
  • "Ruthenium-Catalyzed Ortho C-H Arylation of Aromatic Nitriles with Arylboronates and Observation of Partial Para Arylation"
    Koseki, Y.; Kitazawa, K.; Miyake, M.; Kochi, T.; Kakiuchi, F.
    J. Org. Chem., 2017, 82(13), 6503-6510
  • "Syntheses of RuHCl(CO)(PAr3)3 and RuH2(CO)(PAr3)3 Containing Various Triarylphosphines and Their Use for Arylation of Sterically Congested Aromatic C-H Bonds"
    Ogiwara, Y.; Miyake, M.; Kochi, T.; Kakiuchi, F.
    Organometallics, 2017, 36(1), 159-164
  • "Synthesis and Reactivity of Phosphine-Quinolinolato Rhodium Complexes: Intermediacy of Vinylidene and (Amino)carbene Complexes in the Catalytic Hydroamination of Terminal Alkynes"
    Takano, S; Kochi, T.; Kakiuchi, F.
    Organometallics, 2016, 35(24), 4112-4125

総説・解説

  • 「Nondissociative Chain Walking as a Strategy in Catalytic Organic Synthesis」 Kochi, T.; Kanno, S.; Kakiuchi, F., Tetrahedron Lett., 60, 150938, 37, 2019
  • 「Catalytic Reactions of Terminal Alkynes Using Rhodium(I) Complexes Bearing 8-Quinolinolate Ligands 」 Kakiuchi, F.; Takano, S.; Kochi, T., ACS Catal., 8, 6127-6137, 7, 2018
  • 「Selective C−H Functionalizations by Electrochemical Reactions with Palladium Catalyst」 Kakiuchi, F.; Kochi, T., Isr. J. Chem., 57, 953-963, 10-11, 2017

国際会議

  • The 4th International Symposium on Precisely Designed Catalysts with Customized Scaffolding
    "Asymmetric Functionalization of Unreactive Methylene C(sp3)–H Bonds via Chain Walking", Poster Presentation
    Kochi, T.
    2019年12月3日~2019年12月5日, 奈良, 日本
  • The 20th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 20)
    "Development of Effective Strategies for Closure of Catalytic Cycles of Reactions via Palladium-Catalyzed Nondissociative Chain Walking", Poster Presentation
    Kochi, T.; Yamasaki, Y.; Shigekane, M.; Kumagai, T.; Kanno, S.; Kakiuchi, F.
    2019年7月21日~2019年7月25日, Heidelberg, Germany
  • The 47th Naito Conference on C–H Bond Activation and Transformation
    "Selective Functionalization of Unreactive sp3C-HBonds by Chain-Walking Cyclization", Poster Presentation
    Kochi, T.; Hamasaki, T.; Ichinose, K.; Shigekane, M.; Kakiuchi, F.
    2019年7月2日~2019年7月5日, 札幌, 日本
  • The 4th International Conference on Organometallic and Catalysis 2018 (OM&Cat 2018)
    "Nondissociative Chain Walking as an Innovative Strategy for Functionalization of Organic Molecules", Invited Lecture
    Kochi, T
    2018年6月22日~2018年6月25日, Taipei, Taiwan
  • The 1st Sino-Japanese Symposium on Catalysis for Precision Synthesis
    "Chain Walking as an Innovative Strategy for Functionalization of Organic Molecules", Invited Lecture
    Kochi, T
    2018年5月27日~2018年5月30日, Shanghai, China
  • The 19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 19)
    "Chain Walking as a Novel Strategy for Syntheses of Cyclic Organic Molecules from Various 1,n-Dienes", Poster Presentation
    Kochi, T.; Hamasaki, T.; Ichinose, K.; Kakiuchi, F.
    2017年6月25日~2017年6月29日, Jeju, Korea
  • The 2nd International Symposium on Precisely Designed Catalysts with Customized Scaffolding
    "Chain Walking as a Strategy for Catalytic Organic Synthesis", Oral Presentation
    Kochi, T.
    2017年5月12日~2017年5月13日, 吹田, 日本

国内学会(会議)

  • 第33回有機合成化学セミナー
    "革新的な物質活性化法を駆使した新しい触媒的分子変換法の開発", 招待講演
    河内卓彌
    2016年9月6日~2016年9月8日, ニセコ

受賞

  • 「The 20th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 20) Poster Award」
    受賞者:Takuya Kochi
    贈呈元:The 20th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 20)
    受賞日:2019年7月25日

学会運営

  • 「The 4th International Symposium on C-H Activation (ISCHA4)」
    国際会議, Local Committee Member, 2018年8月30日~2018年9月2日, 横浜, 日本